Clinical Efficacy of NST With Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-30

Study Completion Date

2026-03-31

Brief Summary

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The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).

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Detailed Description

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Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction

The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.

curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.

Conditions

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Periodontitis, Adult

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The test group "Group 1" will receive full Scaling and root planing (SRP) followed by subgingival application of ozonated olive gel.

The control group "Group 2" will receive full-mouth SRP followed by subgingival application of curcumin gel

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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curcumin gel

The curcumin gel will be gently deposited into the periodontal pockets to ensure adequate subgingival delivery.

Group Type ACTIVE_COMPARATOR

full mouth non-surgical scaling

Intervention Type PROCEDURE

All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation

ozonated olive gel.

patients will receive subgingival application of ozonated olive oil in the periodontal pocket

Group Type ACTIVE_COMPARATOR

full mouth non-surgical scaling

Intervention Type PROCEDURE

All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation

Interventions

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full mouth non-surgical scaling

All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
2. Patients agree to a 3-month follow-up period and provide an informed consent.

Exclusion Criteria

1. Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
2. Teeth with both endo-perio lesions.
3. Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
4. Anti-inflammatory drugs in the previous 1 month.

6\. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes