The Effect of Hydration on Postprandial Metabolic Responses

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-31

Study Completion Date

2025-12-31

Brief Summary

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Certain populations, such as industrial workers and endurance athletes are particularly susceptible to dehydration due to exposure to heat for long periods of time causing evaporative water loss via sweating. The physical and cognitive decrements associated with dehydration have been widely researched, however the effect of dehydration on metabolism is lesser known. As climate change is causing temperatures to rise, and metabolic diseases such as type 2 diabetes are more common, the effect of dehydration on metabolism, specifically glycemic response to meals, needs to be established for future recommendations in clinical, environmental and athletic settings.

Therefore, the aim of this study is to investigate the effect of acute exercise-induced dehydration on subsequent metabolic responses to feeding (i.e. glycaemia and insulinaemia).

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Detailed Description

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Conditions

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Glycaemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomised, crossover design

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Euhydrated

Light exercise in a hot environment with water ingested to fully replace sweat losses and maintain euhydration.

Group Type EXPERIMENTAL

Water intake

Intervention Type OTHER

Water ingested to fully replace sweat losses during exercise.

Hypohydrated

Light exercise in a hot environment with water restricted to induce hypohydration of \~3% body mass through sweating.

Group Type EXPERIMENTAL

Water restriction

Intervention Type OTHER

Water restriction to induce hypohydration of \~3% body mass through sweat losses during exercise.

Interventions

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Water intake

Water ingested to fully replace sweat losses during exercise.

Intervention Type OTHER

Water restriction

Water restriction to induce hypohydration of \~3% body mass through sweat losses during exercise.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female
* Generally fit and healthy
* Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week

Exclusion Criteria

* \< 18 or \> 45
* Any health condition that may affect study outcomes (e.g., endocrine/liver/renal/cardiovascular disease)
* Any morbidity that affects ability to cycle
* Smoker or vaper

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes