To Compare the Efficacy of Intralesional Saline Versus 35% Trichloracetic Acid (TCA) Peel in the Treatment of Atrophic Acne Scars

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

126 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-01

Study Completion Date

2023-10-31

Brief Summary

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This study aimed to compare the efficacy of intradermal normal saline versus trichloroacetic acid (TCA) in treating atrophic acne scars. Atrophic acne scars are a common and disfiguring complication, with limited research on the use of normal saline.

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Detailed Description

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Acne vulgaris is a common skin problem affecting adolescents and adults. It is the eighth most common skin disease globally, having a prevalence ranging from 35%-85%, with notable variations across different regions and age groups.A randomized controlled trial was conducted at the Dermatology Department, Sheikh Zayed Hospital, Rahim Yar Khan, from 1st April 2023 to 31st October 2023. 126 patients were enrolled. Scar grading was based on Goodman and Baron's Qualitative Scar Classification. The Observer Scar Assessment Scale (OSAS) was used by dermatologists. Patients rated their acne scars using the Visual Disease Severity Scale. Photographs were taken for comparison. Efficacy was defined as ≥50% improvement in the OSAS.

Conditions

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Atrophic Acne Scar Atrophic Acne Scarring

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intralesional Saline for acne scars (Group A)

Intralesional Saline 5 to 10ml injected in the sacrs fortnightly for 3 months

Group Type ACTIVE_COMPARATOR

Intralesional Saline

Intervention Type PROCEDURE

Intralesional Saline injected in scars

Topical Trichloracetic acid for acne scars(Group B)

35% trichloroacetic acid peel was applied to scars monthly for 3 months

Group Type ACTIVE_COMPARATOR

35% trichloracetic acid peel

Intervention Type PROCEDURE

35%Trichloracetic acid peel was applied to scars monthly for 3 months

Interventions

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Intralesional Saline

Intralesional Saline injected in scars

Intervention Type PROCEDURE

35% trichloracetic acid peel

35%Trichloracetic acid peel was applied to scars monthly for 3 months

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age: 13-50 years
* Clinically diagnosed patients of atrophic acne scars on face
* duration of more than 6 months
* no history of any procedural intervention in past 3 months

Exclusion Criteria

* history of keloid, active acne, local infection, skin allergies, hypertrophic scarring, photosensitivity, or history of any comorbidities
* history of use of oral isotretinoin, OCPs, steroids or immunosuppressants
* pregnant or lactating females

Minimum Eligible Age

16 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No