Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

NCT ID: NCT05712837

Last Updated: 2023-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-01

Study Completion Date

2022-11-30

Brief Summary

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To compare the efficacy of 25% trichloroacetic acid peel versus 30% salicylic acid peel in mild to moderate acne vulgaris.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from 01 Jun 2022 to 30th Nov, 2022.

Methodology: A total of 60 patients presented with mild or moderate acne vulgaris were randomized into two groups comprising 30 patients in each group and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Patients in Group A were treated with 25% TCA peel whereas patients in Group B were treated with 30% SA peel. At the end of therapy after 12 weeks, evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS).

Detailed Description

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Conditions

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Acne Vulgaris

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group A 25% TCA

25% TCA peel Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.

Group Type ACTIVE_COMPARATOR

25% TRICHLOROACETIC ACID

Intervention Type DRUG

Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.

Group B 30% SALICYLIC ACID

30% SA peels Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Group Type ACTIVE_COMPARATOR

30% salicylic acid

Intervention Type DRUG

Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Interventions

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25% TRICHLOROACETIC ACID

Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.

Intervention Type DRUG

30% salicylic acid

Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Intervention Type DRUG

Other Intervention Names

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Peeling agent Peeling agent

Eligibility Criteria

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Inclusion Criteria

* Patients with mild or moderate facial acne vulgaris presented in dermatology opd

Exclusion Criteria

* Patients with grade III or IV acne vulgaris
* patients taking any acne medications or had taken oral or topical medications in the past 4 weeks
* pregnant female patients or nursing a baby
* patients with known hypersensitivity to the formulations used in the study or a history of photosensitivity
* hypertrophic scars, keloidal tendency, active or recurrent herpes simplex infection
* active dermatosis
* unrealistic expectations
Minimum Eligible Age

13 Years

Maximum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Combined Military Hospital Abbottabad

OTHER

Sponsor Role lead

Responsible Party

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Dr kiran gul

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cmh abbottabad

Abbottābād, Kpk, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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CMHAtd-ETH-15-Derm-22

Identifier Type: -

Identifier Source: org_study_id

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