Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
NCT ID: NCT06179056
Last Updated: 2024-04-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
48 participants
OBSERVATIONAL
2023-03-01
2024-02-01
Brief Summary
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* To assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
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Detailed Description
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The degree of severity of lesions was determined by the global acne grading system (GAGS)
Microbiological samples were collected from all patients for:
1. Isolation of C. acnes
2. Antibiotic susceptibility testing for C. acnes isolates aganist the most commonly used antibiotics in treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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study group
assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
Microbiological samples were collected from all patients for:
1. Isolation of C. acnes
2. Antibiotic susceptibility testing for C. acnes isolates against the most commonly used antibiotics in the treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
Interventions
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assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
Microbiological samples were collected from all patients for:
1. Isolation of C. acnes
2. Antibiotic susceptibility testing for C. acnes isolates against the most commonly used antibiotics in the treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
Eligibility Criteria
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Inclusion Criteria
* Patients of both sexes.
* Patients with acne vulgaris with different grades
Exclusion Criteria
16 Years
40 Years
ALL
Yes
Sponsors
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Zagazig University
OTHER_GOV
Responsible Party
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Reham Essam
Lecturer of Dermatology
Principal Investigators
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Reham Essam
Role: PRINCIPAL_INVESTIGATOR
Zagazig University
Locations
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Reham Essam
Zagazig, Al Sharqia, Egypt
Countries
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References
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Essam R, Nasr M, Khater MW, Fayez B, Anis N. Anti-microbial impact of non-antibiotic agents; salicylic acid, N-acetylcysteine, and isotretinoin against Cutibacterium acnes in patients with acne vulgaris. Arch Dermatol Res. 2024 Dec 30;317(1):155. doi: 10.1007/s00403-024-03608-7.
Other Identifiers
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10156 IRB
Identifier Type: -
Identifier Source: org_study_id
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