Long-pulsed 1064 nm Nd-YAG Laser Versus TCA 20% in Treatment of Keratosis Pilaris

NCT ID: NCT04797663

Last Updated: 2021-08-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-17
• Study Completion Date: 2021-08-01

Brief Summary

Keratosis pilaris (KP) is a common disorder of keratinization. There are different treatment modalities for KP with variable results. Nd:YAG laser and chemical peels are among these treatment modalities, however, there is no enough evidence in the literature regarding their efficacy. The aim of this study is to assess and compare the efficacy of long pulsed Nd:YAG laser and trichloreacetic acid 20% in treatment of keratosis pilaris.

Detailed Description

Keratosis pilaris (KP) is a genetic disorder of keratinization of hair follicles of skin. It's a very common benign condition that manifests as small, rough folliculocentric keratotic papules, often described as chicken bumps, chicken skin or goose-bumps, in characteristic areas of body, particularly the outer upper arms and thighs.

Trichloreacetic acid (TCA) is a type of chemical peels that is derived from acetic acid by the chlorination of 3 hydrogen ions. It can induce coagulative necrosis of proteins and cells. The depth of action depends on various factors e.g the number of layers applied and its combination with substances that potentiate its action.

Nd: YAG laser is a type of hair removing devices that operates at wave length of 1064nm. This wave length allows for less absorption at the epidermis. It is less absorbed by melanin, which leads to lower side effect and better tolerance but less efficacy in dark skinned patients.

Conditions

Keratosis Pilaris

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Nd-YAG laser

laser hair removal

Group Type: ACTIVE_COMPARATOR

Nd-YAG laser

Intervention Type: DEVICE

laser hair removal device

TCA 20%

chemical peel

Group Type: EXPERIMENTAL

TCA 20%

Intervention Type: DRUG

chemical peel

Interventions

Nd-YAG laser

laser hair removal device

Intervention Type: DEVICE

TCA 20%

chemical peel

Intervention Type: DRUG

Other Intervention Names

1064 nm laser; Trichloroacetic acid

Eligibility Criteria

Inclusion Criteria

• Patients above 18 years with KP.
• Patients with KP affecting back of the trunk, arms, thighs, forearms, legs and buttocks.

Exclusion Criteria

• Pregnant or lactating females.
• Patients who had performed any laser treatment for KP within 6 months prior to the study.
• Patients with history of oral retinoids within 3 months prior to the study.
• Patients with history of hypertrophic scars or keloids.
• Patients who used any topical treatment one month prior to the session.
• Patients with acne affecting the same sites of keratosis pilaris.
• Patients with active skin diseases affecting the area involved with KP e.g. folliculitis and eczema.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Dina Saadi

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Akmal Saad, professor

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

Kasr Alainy

Cairo, , Egypt

Countries

Egypt

References

Hassan AS, Abdel Aziz M, Saadi DG. Clinical and Dermoscopic Evaluation of Trichloroacetic Acid 20% Versus Long-Pulsed 1064-nm Nd-YAG Laser in the Treatment of Keratosis Pilaris. Dermatol Surg. 2022 Aug 1;48(8):838-842. doi: 10.1097/DSS.0000000000003488. Epub 2022 Jun 15.

Reference Type: DERIVED

PMID: 35917264 (View on PubMed)

Other Identifiers

las177

Identifier Type: -

Identifier Source: org_study_id