Efficacy and Safety of a 1064-nm Nd:YAG Picosecond Laser Versus a 1927-nm Fractional Laser for Atrophic Acne Scars.

NCT ID: NCT07153679

Last Updated: 2025-09-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 38 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-01
• Study Completion Date: 2021-08-01

Brief Summary

Atrophic acne scars are common disfiguring skin problems, especially in the Asian population prone to Post-inflammatory Hyperpigmentation (PIH), and their treatment is highly challenging. 1064 nm microlens array picosecond laser (P-MLA) based on optomechanical effect and 1927 nm segmented thulium laser (FTL) based on photothermal effect are two emerging therapeutic techniques, but there is a lack of strict clinical evidence for direct comparison in the Asian population. This study aims to directly compare the clinical efficacy, safety and tolerability of 1064 nm P-MLA and 1927 nm FTL in the treatment of atrophic acne scars in the Asian population through a randomized, half-face controlled, evaluator blind trial.

Conditions

Acne Scar; Acne Scars - Atrophic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

1064-nm Nd:YAG Picosecond Laser Group

1064-nm Nd:YAG Picosecond Laser Device (Picocare 450, WONTECH, Daejeon, South Korea)

Group Type: EXPERIMENTAL

1064-nm Nd:YAG Picosecond Laser

Intervention Type: DEVICE

Treatment was performed using 1064 nm Nd:YAG microlens array picosecond laser (Picocare 450, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.

1927-nm Fractional Thulium Laser Group

1927-nm Fractional Thulium Laser Device (Lavieen, WONTECH, Daejeon, South Korea)

Group Type: EXPERIMENTAL

1927-nm Fractional Thulium Laser

Intervention Type: DEVICE

Treatment was performed using 1927-nm thulium fractional laser (Lavieen, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.

Interventions

1064-nm Nd:YAG Picosecond Laser

Treatment was performed using 1064 nm Nd:YAG microlens array picosecond laser (Picocare 450, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.

Intervention Type: DEVICE

1927-nm Fractional Thulium Laser

Treatment was performed using 1927-nm thulium fractional laser (Lavieen, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Aged between 18 and 40.
• Symmetrical atrophic acne scars on both sides of the face.

Exclusion Criteria

• Uncontrolled active acne.
• Pregnant and lactating women.
• Infectious skin diseases at the treatment site.
• Have taken retinoid drugs orally within the past 6 months.
• Photosensitive individuals or those who have used photosensitive drugs within 2 weeks.
• Keloid constitution.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Second Affiliated Hospital of Xi'an Jiaotong University

OTHER

Sponsor Role: lead

Responsible Party

Weihui Zeng

professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

The second affiliated hospital of Xi'an Jiaotong University

Xi’an, Shanxi, China

Countries

China

Other Identifiers

2021013

Identifier Type: -

Identifier Source: org_study_id