Erythropoietin Gel Effect on Dental Implant Stability

NCT ID: NCT06665451

Last Updated: 2024-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-30

Study Completion Date

2026-07-31

Brief Summary

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* Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.
* The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.
* Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .
* The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .

Detailed Description

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Conditions

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Osseointegration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Test Group

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel .

Group Type EXPERIMENTAL

Erythropoietin gel coated implants

Intervention Type OTHER

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel.

Control group

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Group Type ACTIVE_COMPARATOR

Non coated dental implants

Intervention Type OTHER

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Interventions

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Non coated dental implants

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Intervention Type OTHER

Erythropoietin gel coated implants

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
* Good general periodontal health and maintenance.

Exclusion Criteria

* Heavy smokers who smoke more than ten cigarettes per day
* Acute infected socket
* Ant socket with wall defect.
* Pregnency
* Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
* Patients who had subjected to intravenous and/or oral bisphosphonate therapy.
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Al-Azhar University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Mohsen Farghaly

Principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohamed Alaa Lecturer of OMFS

Role: STUDY_DIRECTOR

faculty of Dental medicine Al-Azhar University

Locations

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Faculty of dental medicine Al-Azhar university

Asyut, Asyut Governorate, Egypt

Site Status

Countries

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Egypt

Central Contacts

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Ahmed Mohsen Principle investigator

Role: CONTACT

00201020994802

Mohamed Mahjob Head of oral and maxillofacial surgery department

Role: CONTACT

00201001544056

Facility Contacts

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Mohamed Mahjob Head of oral and maxillofacial surgery department

Role: primary

00201001544056

Mohamed Alaa Lecturer of OMFS

Role: backup

00201091919870

Ahmed Mohsen Principle investigator

Role: backup

Mohamed Mahjob Head of oral and maxillofacial surgery department

Role: backup

Other Identifiers

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Implant surface modification

Identifier Type: -

Identifier Source: org_study_id

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