Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

NCT ID: NCT06663267

Last Updated: 2024-10-29

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 350000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-11-30
• Study Completion Date: 2028-05-31

Brief Summary

The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:

1. How do meteorological factors and air pollution affect cardiovascular system?

2. What is the interaction between meteorological factors and air pollution on cardiovascular system?

Participants will:

1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound.

2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

Detailed Description

The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.

Conditions

Cardiovascular System; Health

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

High Temperature Group

Participants experiencing temperatures above the 90th percentile for the region, as recorded during the summer months. Temperature data are sourced from local meteorological statio

NOT

Intervention Type: OTHER

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

Low Temperature Group

Includes participants from areas where winter temperatures are below the 10th percentile, based on historical weather data from local meteorological observations

NOT

Intervention Type: OTHER

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

High Pollution Group

Participants in this group are those exposed to high levels of air pollutants

NOT

Intervention Type: OTHER

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

Low Pollution Group

This cohort consists of individuals living in areas with air pollutant levels consistently below the national air quality standards

NOT

Intervention Type: OTHER

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

Interventions

NOT

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

·Relevant records in the physical examination database shall be ≥3 times

·≥18 years old

Exclusion Criteria

• Relevant records in the physical examination database shall be ≥３times
• Serious heart and lung diseases
• Malignant tumors
• Serious mental illness in the past

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Affiliated Hospital of Hangzhou Normal University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

MingWei Wang

Hanzhou, Zhejiang, China

Site Status: RECRUITING

Countries

China

Central Contacts

Mingwei W Wang, PhD

Role: CONTACT

wmw990556@163.com

18758871517 ext. not

Facility Contacts

MingWei W Wang, PhD

Role: primary

wmw990556@163.com

86-18758871517 ext. NOT

References

Clement DL, De Buyzere ML, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, Gheeraert PJ, Missault LH, Braun JJ, Six RO, Van Der Niepen P, O'Brien E; Office versus Ambulatory Pressure Study Investigators. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med. 2003 Jun 12;348(24):2407-15. doi: 10.1056/NEJMoa022273.

Reference Type: BACKGROUND

PMID: 12802026 (View on PubMed)

McCarron P, Smith GD, Okasha M, McEwen J. Blood pressure in young adulthood and mortality from cardiovascular disease. Lancet. 2000 Apr 22;355(9213):1430-1. doi: 10.1016/S0140-6736(00)02146-2.

Reference Type: BACKGROUND

PMID: 10791531 (View on PubMed)

Tandon S, Grande AJ, Karamanos A, Cruickshank JK, Roever L, Mudway IS, Kelly FJ, Ayis S, Harding S. Association of Ambient Air Pollution with Blood Pressure in Adolescence: A Systematic-review and Meta-analysis. Curr Probl Cardiol. 2023 Feb;48(2):101460. doi: 10.1016/j.cpcardiol.2022.101460. Epub 2022 Oct 18.

Reference Type: BACKGROUND

PMID: 36265590 (View on PubMed)

Other Identifiers

AH-2023-005

Identifier Type: -

Identifier Source: org_study_id