The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution

NCT ID: NCT00809432

Last Updated: 2008-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Study Completion Date

2008-08-31

Brief Summary

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Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.

Detailed Description

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Conditions

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Blood Pressure Heart Rate Variability

Keywords

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Air pollution Heart rate Heart rate variability Blood pressure Face mask

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Visit 1

2 hour city centre kerbside walk in Beijing China

Group Type EXPERIMENTAL

No Face mask

Intervention Type OTHER

Subjects will not wear a face mask to reduce their personal exposure to air pollution

Visit 2

2 hour city centre kerbside walk in Beijing China

Group Type EXPERIMENTAL

Face mask (Dust Respirator)

Intervention Type DEVICE

Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.

Interventions

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Face mask (Dust Respirator)

Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.

Intervention Type DEVICE

No Face mask

Subjects will not wear a face mask to reduce their personal exposure to air pollution

Intervention Type OTHER

Other Intervention Names

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3M Dust Respirator 8812

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers

Exclusion Criteria

* Current smokers
* Significant occupational exposure to air pollution
* Regular medication use (except oral contraceptive pill)
* Intercurrent illness
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Peking Union Medical College

OTHER

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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University of Edinburgh

Principal Investigators

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Jeremy P Langrish, MB BCh MRCP

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Medical Union College

Beijing, , China

Site Status

Countries

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China

References

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Langrish JP, Watts SJ, Hunter AJ, Shah AS, Bosson JA, Unosson J, Barath S, Lundback M, Cassee FR, Donaldson K, Sandstrom T, Blomberg A, Newby DE, Mills NL. Controlled exposures to air pollutants and risk of cardiac arrhythmia. Environ Health Perspect. 2014 Jul;122(7):747-53. doi: 10.1289/ehp.1307337. Epub 2014 Mar 25.

Reference Type DERIVED
PMID: 24667535 (View on PubMed)

Other Identifiers

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167/2008/Pilot

Identifier Type: -

Identifier Source: org_study_id