Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators

NCT ID: NCT02736487

Last Updated: 2016-04-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 72 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-11-30
• Study Completion Date: 2015-12-31

Brief Summary

The purpose of this research project is to examine whether short-term use of portable air pollution filtration can result in changes in indoor airborne pollutants and impact on cardiovascular and respiratory health outcomes of the inhabitants.

Detailed Description

This study will focus on evaluating the short-term benefits of a common portable air purifier technology in reducing air pollutant exposure and the anticipated concomitant health impacts. High ambient levels of various air pollutants in the Shanghai area serve as a useful model to test the portable air purifier intervention in a realistic setting. As most people using a portable air purifier would only be able to do so in their residences, the investigators have designed our study only to test residential air purifier use. Our hypothesis is that the reduction in pollutant concentrations in indoor air caused by the air purifier will result in measurable reductions in risk factors for cardiovascular and respiratory diseases.

Conditions

Non-smoking, Healthy Adults

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Group A: True-Washout-Sham

Subjects in group A receives true air filtration intervention, then at least two weeks of washout period, followed by sham air filtration intervention.

Group Type: ACTIVE_COMPARATOR

True-Washout-Sham Air Filtration Intervention

Intervention Type: DEVICE

This intervention involved three sequential steps: (1) 12 to 20 hours of true air filtration intervention; (2) at least two weeks of washout period; (3) 12 to 20 hours of sham air filtration intervention. In the indoor environment, the portable filtration device drew room air, sent it through filter and active carbon (for true filtration) or active carbon alone (sham filtration) and then delivered processed air back to room air. In the study the portable filtration device processes 2.8 cubic meter of room air per minute. The washout period lasted for at least two weeks where no filtration intervention was implemented.

Group B: Sham-Washout-True

Subjects in group B receives sham air filtration intervention, then at least two weeks of washout period, followed by true air filtration intervention.

Group Type: ACTIVE_COMPARATOR

Sham-Washout-True Air Filtration Intervention

Intervention Type: DEVICE

This intervention involved three sequential steps: (1) 12 to 20 hours of sham air filtration intervention; (2) at least two weeks of washout period; (3) 12 to 20 hours of true air filtration intervention. In the indoor environment, the portable filtration device drew room air, sent it through filter and active carbon (for true filtration) or active carbon alone (sham filtration) and then delivered processed air back to room air. In the study the portable filtration device processes 2.8 cubic meter of room air per minute. The washout period lasted for at least two weeks where no filtration intervention was implemented.

Interventions

True-Washout-Sham Air Filtration Intervention

This intervention involved three sequential steps: (1) 12 to 20 hours of true air filtration intervention; (2) at least two weeks of washout period; (3) 12 to 20 hours of sham air filtration intervention. In the indoor environment, the portable filtration device drew room air, sent it through filter and active carbon (for true filtration) or active carbon alone (sham filtration) and then delivered processed air back to room air. In the study the portable filtration device processes 2.8 cubic meter of room air per minute. The washout period lasted for at least two weeks where no filtration intervention was implemented.

Intervention Type: DEVICE

Sham-Washout-True Air Filtration Intervention

This intervention involved three sequential steps: (1) 12 to 20 hours of sham air filtration intervention; (2) at least two weeks of washout period; (3) 12 to 20 hours of true air filtration intervention. In the indoor environment, the portable filtration device drew room air, sent it through filter and active carbon (for true filtration) or active carbon alone (sham filtration) and then delivered processed air back to room air. In the study the portable filtration device processes 2.8 cubic meter of room air per minute. The washout period lasted for at least two weeks where no filtration intervention was implemented.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Healthy, non-smoking adults
• Live in the dormitory building at Shanghai First People's Hospital (South Section).

Exclusion Criteria

• Current smokers
• Has any of the following diseases: chronic respiratory, cardiovascular, liver, renal, hematological disease; diabetes mellitus;
• Has any other diseases that may confound or complicate the effects of the intervention
• Pregnant females

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Duke University

OTHER

Sponsor Role: collaborator

Tsinghua University

OTHER

Sponsor Role: collaborator

Rutgers University

OTHER

Sponsor Role: collaborator

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Feng Li

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Junfeng Zhang, PhD

Role: PRINCIPAL_INVESTIGATOR

Duke University

Yinping Zhang, PhD

Role: PRINCIPAL_INVESTIGATOR

Tsinghua University

Locations

Shanghai First People's Hospital

Shanghai, Shanghai Municipality, China

Countries

China

Other Identifiers

2015[38]

Identifier Type: -

Identifier Source: org_study_id