Commuter Air Pollution Intervention Study

NCT ID: NCT02277002

Last Updated: 2015-03-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-10-31
• Study Completion Date: 2014-11-30

Brief Summary

Traffic related air pollution is a well-recognised and much studied contributor to smog and is linked to a number of adverse health outcomes. Although traffic pollutants can travel long distances, exposure to the highest levels of the raw emissions can occur closest to the source; e.g. in a car in dense traffic conditions. Time spent in-vehicle may contribute up to half of commuters' daily exposure to certain air pollutants. Most new cars now have or allow for a cabin air filter, but it is not known how well cabin air filtration can reduce exposure to traffic-related air pollution.

This intervention study will measure commuters' exposure to air pollutants in rush hour traffic. It will evaluate the impact of this exposure on stress hormones in saliva, and short term cardiopulmonary health indicators such as blood pressure, heart rate variability and respiratory inflammation. It will also look at effects on cognition (mental processing and judgement) in this real world environment where any deficit could be important to safety. In addition, the study will examine whether cabin air filtration can reduce the exposure to traffic related air pollutants and result in improvements in short term cardiopulmonary and cognitive function. This research will contribute to our understanding of how this environment contributes to Canadians' overall air pollution exposure as well as the potential health impacts. It will also test a potentially valuable and economical means of reducing exposure to traffic related air pollution in a commuting environment. The study may also guide the future implementation of the use of cabin filters as an exposure reduction intervention.

Overall Project Objectives:

Can cabin air filtration effectively reduce exposure to traffic related air pollution? Does commuter exposure to air pollution affect short term stress, and cardiopulmonary and cognitive function? Can cabin air filtration mitigate the health effects of commuters' exposure to air pollution?

Conditions

Cognitive Function; Cardiopulmonary Function; Saliva Stress Hormones; Air Pollution Exposure; Lung Inflammation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Placebo

Participants are exposed to unfiltered cabin air

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: OTHER

No Cabin Air Filtration

Cabin Air Filter

Participants are exposed to filtered cabin air

Group Type: ACTIVE_COMPARATOR

Cabin Air Filtration

Intervention Type: DEVICE

Interventions

Cabin Air Filtration

Intervention Type: DEVICE

Placebo

No Cabin Air Filtration

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy Individuals;
• non-smoking.

Exclusion Criteria

• Smokers;
• living in a smoking household;
• currently experiencing seasonal allergies;
• suffering from heart rhythm problems or heart conditions;
• regularly taking corticosteroid medication;
• pregnant or breastfeeding;
• allergic to latex;
• sensitivity to adhesives

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Health Canada

OTHER_GOV

Sponsor Role: lead

Responsible Party

Gary Mallach

Air Health Effects Researcher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Gary Mallach

Role: PRINCIPAL_INVESTIGATOR

Health Canada

Locations

Guy-Favreau Complex

Montreal, Quebec, Canada

Countries

Canada

Other Identifiers

REB 2014-0006

Identifier Type: -

Identifier Source: org_study_id