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Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison

NCT ID: NCT06749093

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-01

Study Completion Date

2029-12-31

Brief Summary

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Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.

Detailed Description

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Healthy adult participants (total 48; 24 of each biological sex assigned at birth) will breathe filtered air (control), wood smoke (WS), diesel exhaust (DE), and DE plus WS (DEWS) each for 2 hours, with 4 weeks between each exposure (washout). Before and after each exposure, participants will answer questions, perform breathing tests, and give blood samples. At 24 hours after each exposure, participants will undergo a bronchoscopy to collect samples from their lungs.

The study will look at what (if any) are the differences between breathing in fresh air (filtered air - FA) or polluted air containing either wood smoke (WS), diesel exhaust (DE) or diesel exhaust plus wood smoke (DEWS). The research team will use wood smoke generated from pine wood, since it is one of the most common types of wood found in Western Canadian forests where forest fires occur.

The investigators will evaluate multiple endpoints as detailed in the Outcome Measures section. For each applicable endpoint, the investigators will evaluate stratified analyses and effect modification by biological sex, participant age, gene score, and microbiomes.

Conditions

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Healthy Individuals Allergic Rhinitis

Keywords

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Air Pollution Wood Smoke Diesel Exhaust

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Filtered Air (FA)

Participants will be exposed to 2 hours of high-efficiency particulate air (HEPA) filtered air (FA).

Group Type PLACEBO_COMPARATOR

Filtered Air (FA)

Intervention Type OTHER

Exposure to HEPA filtered air, as a control

Wood Smoke (WS)

Participants will be exposed to 2 hours of controlled wood smoke (WS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group Type ACTIVE_COMPARATOR

Wood Smoke (WS)

Intervention Type OTHER

Wood smoke (WS) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Diesel Exhaust (DE)

Participants will be exposed to 2 hours of controlled diesel exhaust (DE) as a model of traffic-related air pollution (TRAP) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group Type ACTIVE_COMPARATOR

Diesel Exhaust (DE)

Intervention Type OTHER

Diesel exhaust (DE) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Diesel Exhaust and Wood Smoke (DEWS)

Participants will be exposed to 2 hours of combined controlled diesel exhaust (DE) and wood smoke (DEWS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group Type ACTIVE_COMPARATOR

Diesel Exhaust and Wood Smoke (DEWS)

Intervention Type OTHER

Combined diesel exhaust and wood smoke standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Interventions

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Filtered Air (FA)

Exposure to HEPA filtered air, as a control

Intervention Type OTHER

Wood Smoke (WS)

Wood smoke (WS) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Intervention Type OTHER

Diesel Exhaust (DE)

Diesel exhaust (DE) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Intervention Type OTHER

Diesel Exhaust and Wood Smoke (DEWS)

Combined diesel exhaust and wood smoke standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Intervention Type OTHER

Other Intervention Names

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Traffic-Related Air Pollution Air Pollution

Eligibility Criteria

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Inclusion Criteria

* Age 19-40
* Healthy, with no history of respiratory disease
* Lifetime non-smoker and non-vaper.

Exclusion Criteria

* Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)
* Frequent WS or DE exposures (e.g. home fireplace used for heating/cooking, or employment in transportation, mining, or as a firefighter).
Minimum Eligible Age

19 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Christopher Carlsten

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chris Carlsten, MD

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia

Locations

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University of British Columbia

Vancouver, British Columbia, Canada

Site Status

Countries

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Canada

Central Contacts

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Agnes Yuen

Role: CONTACT

Phone: 604-875-4111

Email: [email protected]

Parteek Johal

Role: CONTACT

Phone: 604-875-5132

Facility Contacts

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Agnes Yuen, BSc

Role: primary

PJ Johal, BSc

Role: backup

Other Identifiers

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H24-00776

Identifier Type: -

Identifier Source: org_study_id