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Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health

NCT ID: NCT01256957

Last Updated: 2016-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2009-04-30

Brief Summary

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The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.

Detailed Description

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The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.

Conditions

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Endothelial Function Oxidative Stress Systemic Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Indoor air HEPA filtration

HEPA filters operating in the participant's bedroom and living room.

Group Type ACTIVE_COMPARATOR

HEPA filter

Intervention Type DEVICE

Control

Control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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HEPA filter

Intervention Type DEVICE

Other Intervention Names

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Honeywell model 50300 Honeywell model 18150

Eligibility Criteria

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Inclusion Criteria

* 19 years or older
* Non-smoking household
* Lives in study region (Smithers or Telkwa British Columbia)

Exclusion Criteria

\-
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role collaborator

Health Canada

OTHER_GOV

Sponsor Role collaborator

Ministry of Environment, British Columbia

OTHER

Sponsor Role collaborator

Simon Fraser University

OTHER

Sponsor Role lead

Responsible Party

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Ryan Allen

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ryan Allen, PhD

Role: PRINCIPAL_INVESTIGATOR

Simon Fraser University

Locations

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Simon Fraser University

Burnaby, British Columbia, Canada

Site Status

Countries

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Canada

References

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Allen RW, Carlsten C, Karlen B, Leckie S, van Eeden S, Vedal S, Wong I, Brauer M. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med. 2011 May 1;183(9):1222-30. doi: 10.1164/rccm.201010-1572OC. Epub 2011 Jan 21.

Reference Type DERIVED
PMID: 21257787 (View on PubMed)

Other Identifiers

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869329

Identifier Type: -

Identifier Source: org_study_id