Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2014-10-21
2016-11-04
Brief Summary
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We enrolled 40 nonsmoking older adults into a randomized double-blind crossover intervention study with daily CV health outcomes and PM2.5 exposure measurements. The study was conducted in a low-income senior living apartment building in downtown Detroit, Michigan.
Participants were exposed to three 3-day scenarios separated by one-week washout periods: unfiltered ambient air (control), low-efficiency (LE) "HEPA-type", and high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence.
The primary outcome was brachial blood pressure (BP). Secondary outcomes included noninvasive aortic hemodynamics and pulse wave velocity and heart rate variability. PM2.5 exposures were measured in the participants' residences as well as by personal-level monitoring.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Sham
Participants were exposed to unfiltered ambient air (sham) filtered air using air filtration systems in the bedroom and main living space of each residence.
Air filtration systems without filters (sham)
Subjects were exposed to unfiltered air.
Low efficiency
Participants were exposed to low-efficiency (LE) "HEPA-type" filtered air using air filtration systems in the bedroom and main living space of each residence.
Low efficiency air filtration systems
Subjects were exposed to low-efficiency filtered air.
High efficiency
Participants were exposed to high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence.
High efficiency air filtration systems
Subjects were exposed to high-efficiency filtered air.
Interventions
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Low efficiency air filtration systems
Subjects were exposed to low-efficiency filtered air.
High efficiency air filtration systems
Subjects were exposed to high-efficiency filtered air.
Air filtration systems without filters (sham)
Subjects were exposed to unfiltered air.
Eligibility Criteria
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Inclusion Criteria
* non-smoking healthy adults
Exclusion Criteria
* had a cardiovascular event within the past 6 months (such as myocardial infarction (heart attack), angina, cardiac or carotid surgery or stent, diagnosed peripheral arterial disease, aortic aneurysms, treated heart failure, any treated arrhythmia including atrial fibrillation)
* have renal disease requiring dialysis.
* have had medication changes in the past 6 weeks.
* use supplementary oxygen.
50 Years
85 Years
ALL
Yes
Sponsors
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University of Michigan
OTHER
Michigan State University
OTHER
Responsible Party
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Masako Morishita
Associate Professor
References
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Morishita M, Adar SD, D'Souza J, Ziemba RA, Bard RL, Spino C, Brook RD. Effect of Portable Air Filtration Systems on Personal Exposure to Fine Particulate Matter and Blood Pressure Among Residents in a Low-Income Senior Facility: A Randomized Clinical Trial. JAMA Intern Med. 2018 Oct 1;178(10):1350-1357. doi: 10.1001/jamainternmed.2018.3308.
Other Identifiers
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