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The Role of Nitric Oxide Synthase Isoforms in the Cardiovascular Effects of Air Pollution

NCT ID: NCT00845169

Last Updated: 2014-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2013-06-30

Brief Summary

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Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. Recently, it has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. The mechanism underlying these detrimental vascular is unclear, but is thought to be via oxidative stress and altered bioavailability of endogenous nitric oxide. In these studies we plan to elucidate the role of endogenous nitric oxide synthase isoforms (NO) in the adverse vascular responses observed following exposure to diesel exhaust.

Detailed Description

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Conditions

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Endothelial Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Diesel Exposure

1 hour exposure to diesel exhaust at 300 µg/m3 during intermittent exercise

Group Type EXPERIMENTAL

Forearm vascular study

Intervention Type PROCEDURE

Forearm venous occlusion plethysmography to measure forearm blood flow during intrabrachial infusion of nitric oxide synthase inhibitors L-NMMA (2-8 µg/min), S-methionyl-L-citrulline (25-200 nmol/min) and 1400W (100-1000 nmol/min) and positive control norepinephrine (60-540 pmol/min)

Air Exposure

1 hour exposure to filtered air during intermittent exercise

Group Type EXPERIMENTAL

Forearm vascular study

Intervention Type PROCEDURE

Forearm venous occlusion plethysmography to measure forearm blood flow during intrabrachial infusion of nitric oxide synthase inhibitors L-NMMA (2-8 µg/min), S-methionyl-L-citrulline (25-200 nmol/min) and 1400W (100-1000 nmol/min) and positive control norepinephrine (60-540 pmol/min)

Interventions

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Forearm vascular study

Forearm venous occlusion plethysmography to measure forearm blood flow during intrabrachial infusion of nitric oxide synthase inhibitors L-NMMA (2-8 µg/min), S-methionyl-L-citrulline (25-200 nmol/min) and 1400W (100-1000 nmol/min) and positive control norepinephrine (60-540 pmol/min)

Intervention Type PROCEDURE

Other Intervention Names

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1400W SMTC L-NMMA Noreadrenaline NorAd

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers

Exclusion Criteria

* Regular medication use (except oral contraceptive pill)
* Current smokers
* Significant occupational exposure to air pollution
* Intercurrent illness
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NHS Lothian

OTHER_GOV

Sponsor Role collaborator

Umeå University

OTHER

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Jeremy Langrish

Clinical Lecturer and Specialty Registrar in Cardiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anders Blomberg, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Umeå University

David E Newby, PhD FRCP

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Umeå University

Umeå, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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DNR 08-185M/2

Identifier Type: -

Identifier Source: org_study_id