Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease

NCT ID: NCT04541498

Last Updated: 2022-01-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 150000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-01-01
• Study Completion Date: 2022-01-01

Brief Summary

Despite the fact that the topic of air pollution has been in focus of researchers for many years, there are no big studies that take up the matter of its influence on acute coronary, cerebral syndromes and CVD mortality in Europe. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution on cardiovascular diseases and CVD mortality in Poland.

Detailed Description

Air quality and its impact on health was put in the spotlight since the infamous Great Smog of London. Since then, it became clear that adverse effects are serious and can no longer be ignored. According to the World Health Organization (WHO) estimations, in last year ambient air pollution caused 4,200,000 deaths worldwide. These statistics included a total of 29,165 deaths that were attributed to air pollution in Poland.

The vast of studies are conducted in highly polluted areas, in which patients are exposed to extreme concentrations like China oraz Indie. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution and cardiovascular diseases in Poland.

Data on morbidity and mortality were collected from the National Statistical Office in Poland. The data of air pollutions and gases were obtained from Voivodeship Inspectorate for Environmental Protection. The daily meteorological data were obtained from the Institute of Meteorology and Water Manageme

Conditions

Pollution; Exposure; Acute Coronary Syndrome; Chronic Coronary Insufficiency; Particulate Matter Inhalation Injury; Cardiovascular Diseases; Cardiovascular Risk Factor

Study Design

• Observational Model Type: CASE_CROSSOVER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Population of Poland

Exposure to short term long term effects of air pollution and climate change

Impact of air pollution and climate changes

Intervention Type: OTHER

To assess the short- and long- term impact of air pollution and climate changes

Patients with Acute Coronary and Cerebral Syndromes

Exposure to short term long term effects of air pollution and climate change

Impact of air pollution and climate changes

Intervention Type: OTHER

To assess the short- and long- term impact of air pollution and climate changes

Interventions

Impact of air pollution and climate changes

To assess the short- and long- term impact of air pollution and climate changes

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• residents from analysed area.

Exclusion Criteria

• none

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medical University of Bialystok

OTHER

Sponsor Role: lead

Responsible Party

Lukasz Kuzma

MD, PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Lukasz Kuzma, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Bialystok, Department of Invasive Cardiology

Locations

Department of Invasive Cardiology Medical University of Białystok 24A M. Skłodowskiej-Curie St.

Bialystok, , Poland

Countries

Poland

References

Kuzma L, Pogorzelski S, Struniawski K, Dobrzycki S, Bachorzewska-Gajewska H. Effect of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients. Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15064. Epub 2019 Nov 19.

Reference Type: RESULT

PMID: 31742576 (View on PubMed)

Kuzma L, Pogorzelski S, Struniawski K, Bachorzewska-Gajewska H, Dobrzycki S. Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry). Int J Hyg Environ Health. 2020 Aug;229:113578. doi: 10.1016/j.ijheh.2020.113578. Epub 2020 Aug 3.

Reference Type: RESULT

PMID: 32758862 (View on PubMed)

Kuzma L, Struniawski K, Pogorzelski S, Bachorzewska-Gajewska H, Dobrzycki S. Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Follow-Up. J Clin Med. 2020 Jul 23;9(8):2351. doi: 10.3390/jcm9082351.

Reference Type: RESULT

PMID: 32717977 (View on PubMed)

Kuzma L, Wanha W, Kralisz P, Kazmierski M, Bachorzewska-Gajewska H, Wojakowski W, Dobrzycki S. Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS - Air Pollution Study). Environ Res. 2021 Jun;197:111154. doi: 10.1016/j.envres.2021.111154. Epub 2021 Apr 17.

Reference Type: RESULT

PMID: 33872649 (View on PubMed)

Rogalska E, Kurasz A, Kuzma L, Bachorzewska-Gajewska H, Dobrzycki S, Kozinski M, Sobkowicz B, Tomaszuk-Kazberuk A. Comparing Atrial-Fibrillation Validated Rapid Scoring Systems in the Long-Term Mortality Prediction in Patients Referred for Elective Coronary Angiography: A Subanalysis of the Bialystok Coronary Project. Int J Environ Res Public Health. 2022 Aug 21;19(16):10419. doi: 10.3390/ijerph191610419.

Reference Type: DERIVED

PMID: 36012052 (View on PubMed)

Other Identifiers

UMB-KKI-103

Identifier Type: -

Identifier Source: org_study_id