Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

NCT ID: NCT06624982

Last Updated: 2025-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-08

Study Completion Date

2027-10-01

Brief Summary

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The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Detailed Description

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The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

Conditions

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Alveolar Bone Grafting Bone Healing Tooth Extraction Site Healing Wound Healing

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Non-molar sites with immediate post-extraction ridge expansion

Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

observational study

Intervention Type OTHER

Observational study; alveolar ridge preservation

Non-molar sites with no immediate post-extraction ridge width change

Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

observational study

Intervention Type OTHER

Observational study; alveolar ridge preservation

Molar sites with immediate post-extraction ridge expansion

Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

observational study

Intervention Type OTHER

Observational study; alveolar ridge preservation

Molar sites with no immediate post-extraction ridge width change

Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

observational study

Intervention Type OTHER

Observational study; alveolar ridge preservation

Interventions

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observational study

Observational study; alveolar ridge preservation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult patients (18-75 years)
* Good general health (controlled conditions)
* Controlled periodontal disease
* Scheduled for single tooth extraction with bone graft placement and resorbable membrane
* Tooth to be extracted must have adjacent teeth
* Socket wall integrity

Exclusion Criteria

* Smoking
* Pregnancy
* Active periodontal disease
* Systemic conditions that affect healing
* Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Marquette University

OTHER

Sponsor Role lead

Responsible Party

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Vrisiis Kofina

Director, Advanced Education in Periodontics Program, Assistant Professor of Periodontics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Vrisiis Kofina, DDS, MS

Role: PRINCIPAL_INVESTIGATOR

Marquette University

Locations

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Marquette University School of Dentistry Graduate Periodontics Clinic

Milwaukee, Wisconsin, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Vrisiis Kofina, DDS, MS

Role: CONTACT

4142886521

Samah Rady, DDS

Role: CONTACT

9497962173

Facility Contacts

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Vrisiis Kofina, DDS, MS

Role: primary

4142886521

Arndt Guentsch, DMD, PhD, MHBA, MS

Role: backup

4142886089

Other Identifiers

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HR-4787

Identifier Type: -

Identifier Source: org_study_id

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