Bovine-derived Xenograft With or Without L-PRF for Alveolar Ridge Preservation After Tooth Extraction: a Randomized Controlled Trial

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-20

Study Completion Date

2025-12-09

Brief Summary

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The study is prospective randomized clinical trial that aims to evaluate the adjunctive use of L-PRF in promoting the desired vascularization and bone fill in small and large defects following tooth extraction and report on the long-term implant and patient outcomes

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Detailed Description

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Conditions

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Dental Implants Tooth Extraction Bone Regeneration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Control group (C)

Xenograft + resorbable collagen membrane

Group Type ACTIVE_COMPARATOR

Alveolar ridge preservation using sticky bone

Intervention Type PROCEDURE

In the test group the xenograft will be mixed in with the L-PRF then placed into the socket.

Test group (T)

Xenograft combined with L-PRF + resorbable collagen membrane

Group Type EXPERIMENTAL

Alveolar ridge preservation using sticky bone

Intervention Type PROCEDURE

In the test group the xenograft will be mixed in with the L-PRF then placed into the socket.

Interventions

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Alveolar ridge preservation using sticky bone

In the test group the xenograft will be mixed in with the L-PRF then placed into the socket.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Aged 18 or over.
* Require extraction of anterior or posterior single tooth due to caries, endodontic and prosthetic complications.
* The tooth that requires extraction is bordered by two teeth.
* Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).
* Good compliance and commitment to attend follow-up review appointments.
* Willing to provide informed consent.

Exclusion Criteria

* Localised / generalised periodontitis.
* Presence of acute periapical lesion.
* Bone metabolic disease and/or taking medications that affect bone metabolism.
* Long term use of non-steroidal anti-inflammatory medications.
* History of malignancy, radiotherapy or chemotherapy.
* Pregnant or lactating women.
* Severe bruxism or parafunctional habits.
* Large occlusal discrepancies.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes