Sticky Bone Compared to A-PRF(Platlet Rich Fibrin) Effect on Alveolar Ridge Preservation

NCT ID: NCT05536492

Last Updated: 2023-10-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-09-07
• Study Completion Date: 2023-10-01

Brief Summary

In this research investigators are going to detect the effect of using different type of materials(sticky bone\platlet rich fibrin ) compared to normal healing on the dimensional changes of alveolar crest after single rooted tooth extraction by using CBCT (cone-beam computed tomography) at time of extraction and after 16-24 weeks

Detailed Description

Patients who are treated and referred for having extractions in the upper and lower arch for single rooted teeth will have CBCT for each patient at time of extraction (T0) and after 3 months (T1) , by using the cross sectional of the CBCT investigators will measure the difference from the middle of the socket to buccal and palatal\lingual walls at 3 different points below the crest 1mm, 3mm , 5mm .

• the thickness of the buccal bone at baseline (T0) at 1, 3 and 5 mm below the crest
• the horizontal ridge width at crest- 1 mm (HW- 1 mm), crest- 3 mm (HW- 3 mm) and crest- 5 mm (HW- 5 mm) at the buccal/palatal side, in millimetres and later transformed to percentages
• the vertical resorption on both buccal and palatal side, in millimetres
• the socket fill defined as the highest point of viewable mineralized bone at the middle of the socket; absolute values (in mm) and percentages were calculated by comparing the initial depth of the socket and the depth after three months of healing preparation of the materials to be augmented : autologous fibrin glue mixed with bone graft(sticky bone) would be prepared by using green tubes by choukroun company centrifuged at 1300 rpm for 14 minutes (using DUE centrifuge) then mixed with 0.5 cc FDBA and the exudate of the compressed A-PRF then applied to the extraction site A-PRF PLUGS will be prepared using red tubes using venous blood centrifuged at 1300 rpm for 14 min , then the compressed using special tray and applied in the extraction sockets

Conditions

A-PRF; ALLOGRAFT

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

G1-Control group

normal socket healing after extraction without intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

G2

SOCKET AUGMENTATION WITH A-PRF ALONE

Group Type: EXPERIMENTAL

A-PRF

Intervention Type: PROCEDURE

EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF

G3

SOCKET AUGMENTATION WITH A-PRF + ALLOGRAFT

Group Type: EXPERIMENTAL

A-PRF

Intervention Type: PROCEDURE

EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF

ALLOGRAFT

Intervention Type: PROCEDURE

EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF + ALLOGRAFT

Interventions

A-PRF

EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF

Intervention Type: PROCEDURE

ALLOGRAFT

EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF + ALLOGRAFT

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• presence of the buccal and palatal/lingual bony walls evaluated clinically by measuring the thickness of the alveolar ridge and radiologically by a CBCT , and residual periodontal attachment of at least 6 mm of single rooted tooth

Exclusion Criteria

• complicated tooth extraction, and any medical problem that could interfere with the mucosal and bony healing processes or contraindicating an implant placement, such as anticoagulation, antiaggregatory medication, radiotherapy, bisphosphonate therapy, diabetes, endocarditis risk factors, immunosuppression, and renal or hepatic failure

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Arab American University (Palestine)

OTHER

Sponsor Role: lead

Responsible Party

Ahmad Nassar

dentist and clinical Msc student

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

ArabAmericanU

Ramallah, West Bank, Palestinian Territories

Countries

Palestinian Territories

Other Identifiers

PHRC/HC/1087/22

Identifier Type: -

Identifier Source: org_study_id