Evaluation of Astaxanthin Properties on Anti-fatigue

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-25

Study Completion Date

2022-09-20

Brief Summary

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Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days. Short-term AST supplementation enhanced endurance performance and effectively reversed cycling challenge-induced muscle damage and lipid peroxidation.

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Detailed Description

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AST is composed of two β-ionone ring systems that are linked by a polyene chain and contain oxygenated keto and hydroxyl moieties, which are responsible for its powerful antioxidant activity. AST has been shown to have numerous health benefits in humans, including improved antioxidant and inflammatory status under different stress conditions. Therefore, this study will explore AST supplement to improve exercise-induced muscle damage and/or physiological anomalies in adults. Ten physically active male adults were randomized into placebo or AST trials and consumed placebo or AST (28 mg/d) supplements orally for 4 days. On day-4, participants performed an exhaustive cycling challenge at 75% V̇O2max, and the time to exhaustion (TTE) was recorded. Blood and gaseous samples were collected before, during, and immediately after cycling to determine changes in muscle damage, inflammation, oxidative stress, and substrate utilization.

Conditions

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Healthy Volunteer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Ten young healthy physically active male college students. Participants were crossed over for AST or placebo supplements, which was completed in four days. Between the crossover trials, participants had a one-week washout period to nullify the effects of the supplement

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

containing edible yellow No. 4, edible yellow No. 5, sucrose, silica, talc, oxidized starch, gelatin, magnesium stearate, and palm wax.

Group Type PLACEBO_COMPARATOR

Placebo (Placebo trial)

Intervention Type OTHER

The Placebo capsule supplement was taken for 4 days (7 capsules per day)

Astaxanthin (AST trial)

Intervention Type OTHER

The AST capsule supplement was taken for 4 days, with a daily dosage of 28 mg of AST (equivalent to 7 capsules per day, each containing 4 mg of AST).

Astaxanthin (AST)

Each capsule containing 4 mg of AST

Group Type EXPERIMENTAL

Placebo (Placebo trial)

Intervention Type OTHER

The Placebo capsule supplement was taken for 4 days (7 capsules per day)

Astaxanthin (AST trial)

Intervention Type OTHER

The AST capsule supplement was taken for 4 days, with a daily dosage of 28 mg of AST (equivalent to 7 capsules per day, each containing 4 mg of AST).

Interventions

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Placebo (Placebo trial)

The Placebo capsule supplement was taken for 4 days (7 capsules per day)

Intervention Type OTHER

Astaxanthin (AST trial)

The AST capsule supplement was taken for 4 days, with a daily dosage of 28 mg of AST (equivalent to 7 capsules per day, each containing 4 mg of AST).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Recruit people who are healthy are 20-40 years male and have exercise habits in college students

Exclusion Criteria

* Have smoking and drinking habits.
* Those who have implanted artificial joints in the past six months and have had recent surgery.
* People who feel unwell due to other reasons during the experiment.
* Take any drugs or Nutrition supplements in the past 3 months.

Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes