The Effects of Chicken Extract on Mental Energy in Healthy Adults and the Underlying Mechanisms

NCT ID: NCT06021223

Last Updated: 2025-09-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 189 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-08-22
• Study Completion Date: 2025-01-08

Brief Summary

This exploratory trial investigates the effect of a chicken extract supplement on mental energy and its potential underlying mechanisms of action among healthy adults using a randomized, double-blind, placebo-controlled clinical trial design. Mental energy is a multi-dimensional construct comprising transient feelings about fatigue, vigor and motivation and cognitive performance in terms of sustained attention and reaction time.

A sub-study investigates the immediate biochemical changes after taking chicken extract.

Conditions

Healthy Adults

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Chicken extract supplement (high-dose)

140ml of chicken extract supplement (high-dose) to be consumed daily for 2 weeks

Group Type: EXPERIMENTAL

Chicken extract supplement (high-dose)

Intervention Type: DIETARY_SUPPLEMENT

140ml of chicken extract supplement (high-dose) to be consumed daily for 2 weeks

Chicken extract supplement (low-dose)

140ml of chicken extract supplement (low-dose) to be consumed daily for 2 weeks

Group Type: EXPERIMENTAL

Chicken extract supplement (low-dose)

Intervention Type: DIETARY_SUPPLEMENT

140ml of chicken extract supplement (low-dose) to be consumed daily for 2 weeks

Placebo

140ml of placebo (caesinate) to be consumed daily for 2 weeks

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: OTHER

140ml of placebo to be consumed daily for 2 weeks

Interventions

Chicken extract supplement (high-dose)

140ml of chicken extract supplement (high-dose) to be consumed daily for 2 weeks

Intervention Type: DIETARY_SUPPLEMENT

Chicken extract supplement (low-dose)

140ml of chicken extract supplement (low-dose) to be consumed daily for 2 weeks

Intervention Type: DIETARY_SUPPLEMENT

Placebo

140ml of placebo to be consumed daily for 2 weeks

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Male or female at 35-64 years of age
• Assessed by investigator to be in good health
• Normal cognition based on investigator's clinical judgement per the routine practice
• Modified PSQI score > 5
• Agree to participate in the study and provide written informed consent
• Agree to abstain from herbal extracts or dietary supplements throughout the study period

Exclusion Criteria

• BMI < 18.5 or ≥ 27 kg/m2
• Concurrent pharmacological treatments
• Current systemic diseases or current/history of neurological or cerebrovascular diseases
• Active peptic ulcer, or a history of peptic ulcer within the last 2 years
• Medications or interventions in the last 4 weeks, which in the investigators' judgement could potentially affect the outcome measures
• Regular significant quantities of dietary supplements or herbal extracts (> 2 times a week) in the last 4 weeks
• Regular excessive caffeine consumption, heavy alcohol consumption or heavy habitual smokers
• Any drastic changes in lifestyle (including diet, smoking, sleep, exercise, and mental and physical activities) in the last 4 weeks
• Not able to maintain the same lifestyle throughout the study period
• Inadequate visual and auditory acuity to allow neuropsychological testing per investigator's judgment
• Inability to undergo fMRI scan
• Any consumption of chicken extract supplement, or carnosine or anserine supplement, in the preceding 4 weeks
• History of allergy to caseinate, milk, or chicken meat
• Women who are pregnant or lactating or intending to do so
• Current enrolment in another interventional study
• Subjects who show unstable sleep habits during the previous month
• Excessive blood donation or blood drawn prior to baseline

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Taipei Medical University Shuang Ho Hospital

OTHER

Sponsor Role: collaborator

Brand's Suntory Asia

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Taipei Medical University Hospital Shuang Ho Hospital

New Taipei City, , Taiwan

Countries

Taiwan

Other Identifiers

BEC-002

Identifier Type: -

Identifier Source: org_study_id