Prolonged Mechanical Ventilation in Neurosurgical Patients:

NCT ID: NCT06591624

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 340 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-01-10
• Study Completion Date: 2023-12-31

Brief Summary

The study was carried out at the neurosurgical operating theater and neurosurgical intensive care unit, Maharaj Nakorn Chiang Mai University-Hospital. The study design was a retrospective Cohort study, recruited elective adult neurosurgical patients during December 1, 2021 to December 31, 2022. The patients were excluded if they had pre-operative definite airway control. The primary outcome was extubation success in the operating theater. Prolonged mechanical ventilation (PMV) means the patients who could not undergo the weaning protocol and extubation in 48 hours of surgery. The secondary outcome was the features associated with the prolonged mechanical ventilation.

Detailed Description

Extubation in operating theater after elective intracranial surgery is superlative. Early extubation strategy should be planned in preoperative period jointly with neurosurgical team. Any deviations from the plan should be identified, whether they originated from surgical aspects or anesthetic managements. The time-point for extubation in neurosurgical patients is more challenging compared to other non-brain surgeries. We identified some potential prognostic impacts to prolonged mechanical ventilation in elective neurosurgical patients.

The study was approved by the Institution Research Ethics Committee Panel 5, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. (ANE-2565-09317). The study was carried out at the neurosurgical operating theater and neurosurgical intensive care unit, Maharaj Nakorn Chiang Mai University-Hospital. The study design was a retrospective Cohort study, recruited elective adult neurosurgical patients during December 1, 2021 to December 31, 2022. The patients were excluded if they had pre-operative definite airway control. The primary outcome was extubation success in the operating theater. Prolonged mechanical ventilation (PMV) means the patients who could not undergo the weaning protocol and extubation in 48 hours of surgery. The secondary outcome was the features associated with the prolonged mechanical ventilation. For continuous data, we used the student's t-test. For categorical data, we used the Fisher's exact or Chi-square test. Univariate analysis and multiple logistic regression were used to identified the prognostic factors. P values < 0.05 indicated statistical significance.

Conditions

Neurosurgical Procedures; Neurosurgical Patients; Prolonged Mechanical Ventilation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

elective adult neurosurgical patients succesfully extubation after neurosurgery

succesfully extubation after neurosurgery

remain intubation after surgery

Intervention Type: OTHER

could not extubated after surgery and prolong mechanical ventilation for 48 hours

elective adult neurosurgical patients prolonged mechanical ventilation

prolonged mechanical ventilation

Prolonged Mechanical Ventilation

Intervention Type: OTHER

The neurosurgical patients who could extubated within 24 h after surgery

Interventions

Prolonged Mechanical Ventilation

The neurosurgical patients who could extubated within 24 h after surgery

Intervention Type: OTHER

remain intubation after surgery

could not extubated after surgery and prolong mechanical ventilation for 48 hours

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• adult neurosurgical patients
• undergo elective surgery

Exclusion Criteria

• already intubation before neurosurgical procedures
• tracheostomy

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chiang Mai University

OTHER

Sponsor Role: lead

Responsible Party

Pathomporn Pin on, M.D.

Associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Chiang Mai University

Chiang Mai, Chiang Mai, Thailand

Countries

Thailand

Other Identifiers

Chiang Mai University

Identifier Type: OTHER

Identifier Source: secondary_id

ANE-2565-09317

Identifier Type: -

Identifier Source: org_study_id