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Patient-ventilator Asynchrony in Patients With Brain Injury

NCT ID: NCT03212482

Last Updated: 2020-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-15

Study Completion Date

2020-02-29

Brief Summary

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Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index \> 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.

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Detailed Description

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Conditions

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Brain Injuries Mechanical Ventilation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* 1\) \]older than 18 years 2) with brain injury in the ICU 3) mechanical ventilated for at least 72 hours

Exclusion Criteria

* 1\) ICU length of stay less than 24 hours 2) enrolled in another trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jian-Xin Zhou

OTHER

Sponsor Role lead

Responsible Party

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Jian-Xin Zhou

Doctoral Student Supervisor， chief of the department and Deputy Dean of the hospital

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jian-Xin Zhou, MD

Role: STUDY_CHAIR

Acute Brain Injury and Critical Care Research Collaboration, ABC Research Collaboration

Locations

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Jian-Xin Zhou

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Luo XY, He X, Zhou YM, Wang YM, Chen JR, Chen GQ, Li HL, Yang YL, Zhang L, Zhou JX. Patient-ventilator asynchrony in acute brain-injured patients: a prospective observational study. Ann Intensive Care. 2020 Oct 19;10(1):144. doi: 10.1186/s13613-020-00763-8.

Reference Type DERIVED
PMID: 33074406 (View on PubMed)

Other Identifiers

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KY 2017-028-02

Identifier Type: -

Identifier Source: org_study_id

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