Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord
NCT ID: NCT06548776
Last Updated: 2025-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
13 participants
INTERVENTIONAL
2024-09-04
2028-07-31
Brief Summary
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Detailed Description
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Establish the feasibility and spectrum of MRS for adult patients while mapping the total spine spectrum at short TEs to allow for future comparison with patients to assess spinal cord lesions malignant potential and grade.
Secondary Objective:
Test success of the spectrum by implementing the protocol on 3 low volume LMD receiving LMD receiving CSI. This will allow us to test reproducibility of the protocol and test effect of radiation on spinal cord at different time frames. This will serve as secondary data for subsequent trials targeting functional statues after radiation and tumor grading predictability of MRS.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Healthy Volunteers
Participants will be recruited from DI volunteer pool to implement MRS spine on.
Magnetic Resonance Spectroscopy (MRS) Scan
Participants will receive MRS Scan
Patients
Participants will be recruited from DI volunteer pool to implement MRS spine on.
Magnetic Resonance Spectroscopy (MRS) Scan
Participants will receive MRS Scan
Interventions
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Magnetic Resonance Spectroscopy (MRS) Scan
Participants will receive MRS Scan
Eligibility Criteria
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Inclusion Criteria
* Adults \> 18 years
* Healthy with no malignancy, demyelinating disease, back pain, degenerative disease, or spinal cord lesions.
* Consent able patients.
Patients with low volume LMD to receive treatment CNS radiation:
* Adults \> 18 years old.
* MR or CSF with evidence of LMD.
* Patients to receive CSI as part of standard treatment of LMD disease.
* Consent able patients, willingness and ability to comply with the study procedures.
* No spinal cord lesions only LMD disease
* Recruitment by radiation oncology faculty in consultation with Dr. De. . .
Exclusion Criteria
* Age \< 18 years
* Pregnant or breastfeeding individuals.
* History of cancer.
* History of spinal cord lesions including malignant, demyelinating, or inflammatory.
* History of prior spinal surgery.
* History of implantable devices.
* History of MR claustrophobia.
* Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
* Scoliosis.
Patients with LMD:
* Age \< 18 years
* History of spinal cord lesions including malignant, demyelinating, or inflammatory.
* History of prior spinal surgery.
* History of implantable devices.
* History of MR claustrophobia.
* Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
* Scoliosis.
18 Years
ALL
Yes
Sponsors
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M.D. Anderson Cancer Center
OTHER
Responsible Party
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Principal Investigators
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Rami Eldaya, MD
Role: PRINCIPAL_INVESTIGATOR
M.D. Anderson Cancer Center
Locations
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MD Anderson Cancer Center
Houston, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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Related Links
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MD Anderson Cancer Center Website
Other Identifiers
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NCI-2024-06761
Identifier Type: OTHER
Identifier Source: secondary_id
2024-0249
Identifier Type: -
Identifier Source: org_study_id
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