Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury
NCT ID: NCT05681936
Last Updated: 2025-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
225 participants
OBSERVATIONAL
2023-01-01
2027-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cross-sectional study: healthy controls
No interventions assigned to this group
Cross-sectional study: chronic traumatic SCI patients
No interventions assigned to this group
Cross-sectional study: non-traumatic SCI patients with degenerative spondylotic myelopathy
No interventions assigned to this group
Longitudinal study: healthy controls
No interventions assigned to this group
Longitudinal study: acute traumatic SCI patients (< 2 months after SCI)
No interventions assigned to this group
Longitudinal study: patients with neurogenic lower urinary tract dysfunction
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Informed consent
* Willing to take part and follow requirements of the protocol
Cross-sectional study:
* Chronic traumatic SCI (\> 12 months after injury) or
* Diagnosed degenerative spondylotic myelopathy (DCM)
Longitudinal study:
* Acute traumatic SCI (\< 2 months after injury) or
* Patients with neurogenic lower urinary tract dysfunction (NLUTD) who undergo routine tibial nerve stimulation (TNS) treatment as part of their rehabilitation (but independently of this study) at Balgrist University Hospital
Exclusion Criteria
* Contraindications for MRI (presence of pacemaker or other type of stimulator in the body, presence of metallic foreign body in or on the body, etc.); we will comply with the imaging center's (SCMI) guidelines and in case of doubt we will exclude the participant from the study
* No informed consent
* History of psychiatric or neurological disease, apart from those induced by SCI (e.g.epilepsy)
* History of skull opening or head trauma
* Known or suspected non-adherence, drug or alcohol abuse
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
* Women who are pregnant (when uncertain, participants will undergo urine testing) or breastfeeding
* Intention to become pregnant during the course of the study
* Body mass index (BMI) \> 35
* Individuals especially in need of protection (according to Research with Human Subjects published by the Swiss Academy of Medical Sciences)
18 Years
ALL
Yes
Sponsors
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Swiss National Science Foundation
OTHER
Swiss Paraplegic Research, Nottwil
NETWORK
University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Patrick Freund, Prof. Dr. med. Dr. rer. nat.
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
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Balgrist University Hospital
Zurich, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022-00558
Identifier Type: -
Identifier Source: org_study_id
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