MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders
NCT ID: NCT02170155
Last Updated: 2025-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
350 participants
OBSERVATIONAL
2012-12-31
2026-12-31
Brief Summary
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In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with CSM
No interventions assigned to this group
Patients with spinal injury (SCI)
No interventions assigned to this group
Healthy controls
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Informed consent
* Age 18-80
* CSM
Exclusion Criteria
* Seizure
* MRI incompatibility
* Pregnancy
18 Years
80 Years
ALL
Yes
Sponsors
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Foundation Wings For Life
OTHER
Balgrist Foundation
UNKNOWN
University of Zurich
OTHER
Responsible Party
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Locations
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University of Zurich, Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Armin Curt, MD
Role: primary
References
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Pfender N, Jutzeler CR, Hubli M, Scheuren PS, Pfyffer D, Zipser CM, Rosner J, Friedl S, Sutter R, Spirig JM, Betz M, Schubert M, Seif M, Freund P, Farshad M, Curt A, Hupp M. Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy. Front Neurol. 2024 Jun 24;15:1411182. doi: 10.3389/fneur.2024.1411182. eCollection 2024.
Kheram N, Boraschi A, Pfender N, Spiegelberg A, Kurtcuoglu V, Curt A, Schubert M, Zipser CM. Queckenstedt's test repurposed for the quantitative assessment of the cerebrospinal fluid pulsatility curve. Acta Neurochir (Wien). 2023 Jun;165(6):1533-1543. doi: 10.1007/s00701-023-05583-w. Epub 2023 Apr 20.
Zipser CM, Pfender N, Spirig JM, Betz M, Aguirre J, Hupp M, Farshad M, Curt A, Schubert M. Study protocol for an observational study of cerebrospinal fluid pressure in patients with degenerative cervical myelopathy undergoing surgical deCOMPression of the spinal CORD: the COMP-CORD study. BMJ Open. 2020 Sep 21;10(9):e037332. doi: 10.1136/bmjopen-2020-037332.
Other Identifiers
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KEK-ZH-2012-0343/PB_2016-00623
Identifier Type: -
Identifier Source: org_study_id