Comparison of Both Metabolic and Functional Effects Induced by Two Neuromuscular Electrical Stimulation Protocols: A Comprehensive Approach Using Magnetic Resonance Imaging and Spectroscopy

NCT ID: NCT02001675

Last Updated: 2013-12-05

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-12-31
• Study Completion Date: 2016-06-30

Brief Summary

Neuromuscular electrical stimulation (NMES) has emerged as a suitable tool for restoring, maintaining and/or enhancing muscular performance. From a practical point of view, NMES can elicit contractions either by direct activation of motor axons (i.e. peripheral mechanism) or by the recruitment of motoneurons in the spinal cord through the depolarization of sensory axons (central mechanism). It is noteworthy that NMES parameters widely affect the balance between transmission along these two pathways. Conventional NMES is usually delivered using short pulse duration (0.05-0.4 ms), low stimulation frequency (15-40 Hz) and high stimulus intensities so that the large antidromic volley in motor axons ensures that the evoked contraction will be driven largely by the direct depolarization of motor axons beneath the stimulation site with no or little involvement of central nervous system. On the contrary, when NMES is delivered using wide pulse widths (1 ms) and high frequency (up to 100 Hz) (WP-HF NMES), a portion of the evoked contraction arises from a central mechanism and the corresponding force (recently referred to as "extra force") is significantly (three times) larger than the conventional NMES-induced force. This extra force is supposed to represent the central contribution from the recruitment of spinal motoneurons by the evoked afferent volley given that no additional force was observed during a complete anesthetic block of the nerve proximal to the stimulation site. Despite the obvious differences in terms of activation of the neuromuscular system between conventional and WP-HF NMES, the functional, metabolic and cortical responses associated to both protocols remain to be determined

Detailed Description

The main goal of the project will be to characterize the evoked-force profile during conventional and WP-HF NMES.

The secondary purpose will be to i) investigate the anatomic and metabolic responses of the human calf muscle following both NMES protocols by using magnetic resonance imaging (MRI) and 31-phosphorous magnetic resonance spectroscopy (MRS-P31), ii) study the cortical responses for both conditions of stimulation by means of functional MRI (f-MRI).

Conditions

Healthy

Keywords

Neuromuscular electrical stimulation (NMES)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Volunteer healthy

Group Type: EXPERIMENTAL

magnetic resonance imaging (MRI)

Intervention Type: DEVICE

31-phosphorous magnetic resonance spectroscopy (MRS-P31)

Intervention Type: DEVICE

Interventions

magnetic resonance imaging (MRI)

Intervention Type: DEVICE

31-phosphorous magnetic resonance spectroscopy (MRS-P31)

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• age included between 18 and 45 years
• The volunteers will have to benefit from a social security cover.
• The selected subjects will have to be unhurt of any general disease, psychiatric disorders and any infectious, inflammatory, tumoral, vascular, degenerative or traumatic pathology.

They will have to follow no chronic treatment and will have to be unhurt of any history of alcoholism or drug addiction.

Exclusion Criteria

• Usual contraindications for an examination MRI.

So, will not be included, the subjects:

• suffering from claustrophobia,
• having stimulating one cardiac, carriers of a system Holter,
• carriers of hook(staple) (clip) surgical metallic,
• Carriers of a prosthesis or a metallic implant (or quite different metallic foreign bodies),
• carriers of a prosthesis dental (device),
• carriers of a hearing aid,
• carriers of an insulin pump,
• having been hurt by pieces of shrapnel or lead,
• Having had a dislocation, a fracture or a recent surgical operation (less than 6 months before the inclusion),
• Having followed a treatment(processing) with anti-inflammatory drugs during the last 3 months, having followed a treatment(processing) with amino acids during 3

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

michele DAMON

Role: STUDY_DIRECTOR

Assistance Publique Hopitaux De Marseille

Locations

Assistance Publique Hopitaux de Marseille

Marseille, , France

Countries

France

Other Identifiers

2012-32

Identifier Type: OTHER

Identifier Source: secondary_id

2012-A01265-38

Identifier Type: -

Identifier Source: org_study_id