Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate

NCT ID: NCT02934594

Last Updated: 2016-10-17

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-10-31
• Study Completion Date: 2020-08-31

Brief Summary

Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with palliative decompression.

Detailed Description

MSCC patients who underwent palliative decompression after January 2012 in National Taiwan University Hospital (NTUH) were divided into the preoperative motor function intact group (Group A) and motor deficit group (Group B). The motor deficit group was subdivided into operation within 48 hours (Group B1), and after 48 hours (Group B2). All patients underwent palliative decompression and posterior stabilization. Investigators did wide laminectomy for tumor invading the vertebral body, and debulking surgery for tumor destructing the posterior column of the spine. Investigators retrospectively reviewed all patient records, including patient demographics, prognostic factors for survival (Kaplan-Meier survival analysis), neurological outcome (Frankel grade), primary tumor, complications, and relevance of Tomita and Tokuhashi scores.

Conditions

Neoplasm Metastasis; Spinal Cord Compression

Study Design

• Observational Model Type: CASE_ONLY

Study Groups

Group A

Motor function intact group: received palliative decompression

Palliative Decompression

Intervention Type: OTHER

palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2)

Group B1

motor deficit group: received palliative decompression within 48 hours after symptoms occured

Palliative Decompression

Intervention Type: OTHER

palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2)

Group B2

motor deficit group: received palliative decompression 48 hours after symptoms occured

Palliative Decompression

Intervention Type: OTHER

palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2)

Interventions

Palliative Decompression

palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients with metastatic spinal cord compression (MSCC) who underwent palliative decompression in National Taiwan University Hospital after January 1st, 2012.

Exclusion Criteria

• Patients with metastatic spinal cord compression (MSCC) who underwent palliative decompression before December 31st, 2011, or those who were not treated in National Taiwan University Hospital.

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Shu-Hua Yang, M.D., Ph.D.

Role: STUDY_CHAIR

National Taiwan University Hospital

Central Contacts

Shu-Hua Yang, M.D., Ph.D.

Role: CONTACT

005964@ntuh.gov.tw

886-2-23123456 ext. 63981

References

Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 2005 Oct 1;30(19):2186-91. doi: 10.1097/01.brs.0000180401.06919.a5.

Reference Type: BACKGROUND

PMID: 16205345 (View on PubMed)

Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306. doi: 10.1097/00007632-200102010-00016.

Reference Type: BACKGROUND

PMID: 11224867 (View on PubMed)

Other Identifiers

201608007RIND

Identifier Type: -

Identifier Source: org_study_id