Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

NCT ID: NCT06535971

Last Updated: 2025-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-05

Study Completion Date

2025-12-31

Brief Summary

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The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Detailed Description

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The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Past studies investigated the effect of manual therapy of exercise for individuals with hemophilia and found to enhance muscle strength, balance, fitness and promote quality of life. However, less study has evaluated the safety and effectiveness of manual therapy combined with exercise for individuals with multiple hemophilic arthropathy. Therefore, the aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Conditions

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Severe Hemophilia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Physiotherapy group

Individualized physiotherapy intervention based on manual therapy and exercise 1 session per week for 3 months

Group Type OTHER

Manual therapy combined exercise

Intervention Type OTHER

1. Manual therapy included fascia release, progressive passive stretch, mobilization, etc.(depend on subject's current condition)
2. Exercise included muscle strengthening, trunk (spine) stabilization exercise. (depend on subject's current condition)

Interventions

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Manual therapy combined exercise

1. Manual therapy included fascia release, progressive passive stretch, mobilization, etc.(depend on subject's current condition)
2. Exercise included muscle strengthening, trunk (spine) stabilization exercise. (depend on subject's current condition)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* over 20 years old and diagnosed with severe hemophilia
* those who receive prophylaxis regularly
* there are more than 2 target joints (hemophilic arthropathy)

Exclusion Criteria

* unwilling to sign the informed consent
* any neurological disease or specific musculoskeletal condition (such as fracture) one year ago
* more than 3 (excluding 3) joint replacement surgeries (different joints)
* unable to walk due to hemophilia joint disease or any other diseases
* major bleeding events that pose risks or hinder research
* unable to follow instructions due to cognitive impairment
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Far Eastern Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wan Jung Kao, bachelor

Role: PRINCIPAL_INVESTIGATOR

staff

Locations

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Far Eastern Memorial hospital

New Taipei City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Yun Shan Jian

Role: CONTACT

886-2-7728-2819 ext. 2819

Facility Contacts

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Yun-Shan Jian

Role: primary

886-2-7728-2819 ext. 2819

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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FarEasternMH

Identifier Type: REGISTRY

Identifier Source: secondary_id

111296-E

Identifier Type: -

Identifier Source: org_study_id

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