Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises Patient With Hemophilia

NCT ID: NCT05879549

Last Updated: 2025-06-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-15

Study Completion Date

2025-06-01

Brief Summary

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Hemophilia is a bleeding disorder caused by a deficiency of clotting factors in the blood. Muscle and joint bleeding are frequently observed in patients with hemophilia. Lower extremity bleeding can adversely affect balance, gait, and proprioception. The goal of this study; To compare the effectiveness of closed kinetic chain exercises and proprioceptive exercises on balance, proprioception and gait parameters in adolescent and young hemophilic individuals with lower extremity joint involvement.

The main question it aims to answer is:

Are the effects of closed kinetic chain exercises and proprioceptive exercises different on balance and walking in hemophilic individuals?

Detailed Description

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Conditions

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Hemophilia A Hemophilia B

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Closed Chain Exercise Group

Closed kinetic chain exercises will be given under the supervision of a physiotherapist, 2 sessions a week for 12 weeks.

Group Type EXPERIMENTAL

Closed Chain Exercise Group

Intervention Type OTHER

Closed Chain Exercise Group

Proprioceptive Exercise Group

Proprioceptive exercises will be given under the supervision of a physiotherapist, 2 sessions a week for 12 weeks.

Group Type EXPERIMENTAL

Proprioceptive Exercise Group

Intervention Type OTHER

Proprioceptive Exercise Group

Control Group

No intervention will be applied.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Closed Chain Exercise Group

Closed Chain Exercise Group

Intervention Type OTHER

Proprioceptive Exercise Group

Proprioceptive Exercise Group

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Having been diagnosed with Hemophilia A and Hemophilia B
* Having a blood factor level below 5%,
* Between 13-25 years old
* History of bleeding to the lower extremity and target joint
* Total lower extremity Hemophilia joint health score ≥3
* Using prophylaxis

Exclusion Criteria

* Having undergone lower extremity surgery in the last 6 months
* Having a Body Mass Index over 30 kg/m2
* Have an inhibitor
* Using a walking aid
Minimum Eligible Age

13 Years

Maximum Eligible Age

25 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Bahçeşehir University

OTHER

Sponsor Role lead

Responsible Party

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Tuğçe Poyraz İşleyen

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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İstanbul University-Cerrahpaşa

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Tat NM, Tat AM, Oner AF, Karaman K, Kaplan S, Can F. Static postural balance evaluation and an investigation of the relationship with joint health in children with severe haemophilia: a controlled cross-sectional study. Haemophilia. 2021 Mar;27(2):e245-e252. doi: 10.1111/hae.14240. Epub 2021 Jan 24.

Reference Type BACKGROUND
PMID: 33486846 (View on PubMed)

Poyraz Isleyen T, Tarakci E, Leblebici G, Yeldan I, Zulfikar B. Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2025 Apr 24;14:e66770. doi: 10.2196/66770.

Reference Type DERIVED
PMID: 40273449 (View on PubMed)

Other Identifiers

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E-74555795-050.01.04-689576

Identifier Type: -

Identifier Source: org_study_id

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