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The Acute Effects of Blood Flow Restriction on Ankle Muscle Reaction Time and Proprioception in Healthy Individuals

NCT ID: NCT07307339

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-01

Study Completion Date

2026-01-10

Brief Summary

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his randomized controlled crossover study aims to investigate the acute effects of lower limb blood flow restriction (BFR) on ankle joint proprioception, postural control, and muscle activation in healthy adults. Each participant will complete test sessions under BFR (60% individualized arterial occlusion pressure) and control (20 mmHg sham) conditions. Outcome measures include joint position sense, kinesthesia, static and dynamic balance performance, and electromyographic (EMG) activity and reaction times of selected lower limb tibialis anterior and peroneus longus muscles.

Detailed Description

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Lateral ankle sprains are among the most common musculoskeletal injuries and may lead to chronic ankle instability (CAI), partly due to impaired proprioception and neuromuscular control. Blood flow restriction (BFR) training is widely used to augment muscular adaptations with low external loads; however, its acute effects on joint proprioception and sensorimotor control, particularly at the ankle joint, remain unclear and may be detrimental under certain conditions. This randomized controlled crossover trial will examine the effects of a single-session lower limb BFR application on ankle joint position sense, kinesthesia, static and dynamic balance, and EMG-based reaction time and activity of lower limb muscles in healthy adults. Participants aged 18-40 years without recent ankle sprain, neuromuscular, cardiovascular, or thromboembolic disease will undergo standardized proprioception tests using an isokinetic dynamometer, static balance tests on a force platform, Y-balance test, and inversion simulation platform assessments under BFR (60% arterial occlusion pressure) and low-pressure control (20 mmHg) conditions. Individual arterial occlusion pressure (AOP) will be determined using Doppler ultrasound, and BFR will be applied with a pneumatic cuff at the most proximal thigh. All measurements will be performed on the dominant lower limb with sessions scheduled at the same time of day to minimize circadian variability. The primary hypothesis is that acute lower limb BFR will worsen ankle joint proprioception and sensorimotor control compared with the control condition, potentially indicating a transient increase in injury risk during BFR-assisted activities.

Conditions

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Ankle Proprioception Blood Flow Restriction

Keywords

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ankle proprioception blood flow restriction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Arm 1: Experimental - Blood Flow Restriction Participants perform balance and proprioception tests under lower-limb blood flow restriction at 60% arterial occlusion pressure.

Arm 2: Sham Comparator - Sham Blood Flow Restriction Participants perform the same balance and proprioception tests with sham blood flow restriction at 20 mmHg.

This is a randomized crossover study, and all participants complete both conditions in a randomized order.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Blood Flow Restriction

Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Group Type EXPERIMENTAL

Blood Flow Restriction

Intervention Type OTHER

Arm Description: Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Sham BFR

Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Group Type SHAM_COMPARATOR

Sham Blood Flow Restriction

Intervention Type OTHER

Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Interventions

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Blood Flow Restriction

Arm Description: Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Intervention Type OTHER

Sham Blood Flow Restriction

Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged between 18 and 40 years
* No known neuromuscular or cardiovascular disease

Exclusion Criteria

* History or presence of cardiac, coronary artery, or peripheral arterial disease
* Presence or history of varicose veins, hypertension, diabetes mellitus, or pulmonary disease
* History of pulmonary embolism or deep vein thrombosis
* Use of medications affecting the central nervous or cardiovascular systems
* Use of oral contraceptives or anticoagulants
* Pregnancy
* Open wounds or significant scar tissue at the cuff application site
* History of lower extremity musculoskeletal injury or surgery
* Any neurological, vascular, or systemic condition that may interfere with test performance
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Uludag University

OTHER

Sponsor Role lead

Responsible Party

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Melike Tugran

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ufuk sekir

Role: STUDY_DIRECTOR

Department of Sports Medicine, Bursa Uludağ University

Locations

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Uludag University

Bursa, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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2025-15/31

Identifier Type: -

Identifier Source: org_study_id