Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention

NCT ID: NCT05951036

Last Updated: 2025-06-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-17
• Study Completion Date: 2024-11-30

Brief Summary

The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman. The main questions it aims to answer are:

1. Does LL-BFR improve muscle strength better than sham LL-BFRt and HL-Et?

2. Does LL-BFR improve dynamic stability better than sham LL-BFRt and HL-Et?

3. Does LL-BFR prevent ACL injury better than sham LL-BFRt and HL-Et?

Participants will be randomized into three intervention groups: LL-BFRt, sham LL-BFRt, and HL-Et. Participants will be asked to do:

• In LL-BFRt, participants will be asked to do LL eccentric training (including double leg squats, split squats, deadlifts, and monster walks) with a 30% of repetition maximum (RM) and 70% of arterial occlusion pressure (AOP).
• In sham LL-BFRt, participants will be asked to do LL eccentric training with a 30% of repetition maximum (RM) and 10% of arterial occlusion pressure (AOP).
• In HL-Et, participants will be asked to do LL eccentric training with a 70% of repetition maximum (RM).

Researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et to see if muscle strength, dynamic stability, and ACL injury prevention improve after the interventions and follow-up.

Detailed Description

Participants will be asked to do five sets of ten repetitions of each eccentric training, one-minute rest interval for each eccentric training and two mins rest interval between each set.

Conditions

Healthy Subjects; Sports Level 1

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

LL-BFRt

30% of repetition maximum and 70% of arterial occlusion pressure

Group Type: EXPERIMENTAL

Low-load Blood Flow Restriction training

Intervention Type: PROCEDURE

Physical therapist will apply the BFR cuffs with 70% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

Sham LL-BFRt

30% of repetition maximum and 10% of arterial occlusion pressure

Group Type: SHAM_COMPARATOR

Sham Low-load Blood Flow Restriction training

Intervention Type: PROCEDURE

Physical therapist will apply the BFR cuffs with 10% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

HL-Et

70% of repetition maximum

Group Type: ACTIVE_COMPARATOR

High-load Eccentric training

Intervention Type: PROCEDURE

Physical therapist will ask participants to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 70% of repetition maximum.

Interventions

Low-load Blood Flow Restriction training

Physical therapist will apply the BFR cuffs with 70% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

Intervention Type: PROCEDURE

Sham Low-load Blood Flow Restriction training

Physical therapist will apply the BFR cuffs with 10% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

Intervention Type: PROCEDURE

High-load Eccentric training

Physical therapist will ask participants to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 70% of repetition maximum.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Being 15-35 years old
• Perform sports level 1 (soccer, basket ball, futsal, combat martial art) at least twice per week.
• Never had an history of ACL injury
• Never had an history of sprain or strain grade III
• Agree to participate until the end of this study period and sign the inform consent

Exclusion Criteria

• Having hypertension, blood circulation disease, anemia, obesity, diabetes, kidney failure, vena thromboembolic, cancer, and tumor.
• Disabilities or disabled people.

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Udayana University

OTHER

Sponsor Role: lead

Responsible Party

I Putu Gde Surya Adhitya

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Physical therapy laboratory, College of Medicine, Universitas Udayana and ROM Physiotherapy Private Clinic Denpasar

Denpasar, Bali, Indonesia

Countries

Indonesia

References

Adhitya IPGS, Aryana IGNW, Kurniawati I, Thanaya SAP, Utama MBR. Effect of Low-Load Blood Flow Restriction Training and High-Load Resistance Training on Quadriceps Strength, Dynamic Stability, and Functional Performance. Clin J Sport Med. 2025 Feb 11. doi: 10.1097/JSM.0000000000001330. Online ahead of print.

Reference Type: DERIVED

PMID: 39932234 (View on PubMed)

Other Identifiers

1575/UN14.2.2.VII.14/LT/2023

Identifier Type: -

Identifier Source: org_study_id