Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia

NCT ID: NCT07259356

Last Updated: 2025-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-01

Study Completion Date

2026-03-01

Brief Summary

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In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.

Detailed Description

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Conditions

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Hemophilia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Control Condition

Sham-BFR Leg Press Exercise

Group Type ACTIVE_COMPARATOR

Control

Intervention Type DEVICE

Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)

Intervention Condition

BFR Leg Press Exercise

Group Type EXPERIMENTAL

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Intervention Type DEVICE

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Interventions

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Control

Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)

Intervention Type DEVICE

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* patients with haemophilia
* Ability for an exercise intervention

Exclusion Criteria

* Sickle Cell Anemia
* Intravascular stents/bypasses
* Open Wounds/Infections of the lower extremity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Alexander Franz

Prinicipal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital Bonn

Bonn, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

Other Identifiers

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2024_H

Identifier Type: -

Identifier Source: org_study_id

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