Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis
NCT ID: NCT00414557
Last Updated: 2006-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
107 participants
INTERVENTIONAL
2004-05-31
2006-12-31
Brief Summary
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Detailed Description
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This study investigates the effects of quadriceps strengthening on the adduction moment in patients with medial knee OA with and without malalignment. 107 participants with and without varus knee malalignment were recruited and randomised into an exercise or a control group. Participants in the exercise group were taught five quadriceps strengthening exercises by a project physiotherapist to be performed five days a week for twelve weeks at home. The exercises were:
1. Quadriceps exercise over fulcrum using ankle weight
2. Straight leg raise exercise using ankle weight
3. Long arc knee extension exercise in sitting using ankle weight
4. Knee extension exercise with isometric hold at 60° knee flexion using ankle weight
5. Knee extension exercise with isometric hold at 60° knee flexion using an elastic band.
Each exercise was performed at 2x10 repetitions for the first 2 weeks and 3x10 repetitions thereafter.
Participants visited the physiotherapist 7 times at Week 1, 2, 3, 4, 5, 7 and 10. They were given the ankle weights and elastic band to bring home and instructed about the repetitions and weights to use by the physiotherapist, who also checked and progressed their exercises. The average duration of the physiotherapy sessions was 30 minutes. To monitor compliance, each participant was given an exercise instructions sheet and kept a training diary to record the exercises they had done.
The control group received no intervention.
Conditions
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Keywords
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Interventions
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Quadriceps strengthening
Eligibility Criteria
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Inclusion Criteria
* Osteophytes on knee x-ray
* Self-reported pain on the inner aspect of the study knee
* Osteophytes in the medial compartment of the knee joint and
* Medial joint space narrowing greater than lateral joint space narrowing on x-ray
Exclusion Criteria
* History of lower limb joint replacements
* Systemic arthritic conditions such as rheumatic or psoriatic arthritis
* Valgus knee deformity (\> 5º)
* Inability to walk without the use of walking aids
* Intending to start a lower limb strengthening program in the next 3 months
* Seeking or currently receiving physiotherapy for OA knee
50 Years
ALL
No
Sponsors
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Australian Physiotherapy Research Foundation
OTHER
United Pacific Industries
UNKNOWN
University of Melbourne
OTHER
Principal Investigators
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Kim Bennell, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Melbourne
Rana Hinman, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Melbourne
Tim Wrigley, MSc
Role: PRINCIPAL_INVESTIGATOR
University of Melbourne
Boon W Lim, MSc
Role: PRINCIPAL_INVESTIGATOR
University of Melbourne
Leena Sharma, MD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University Medical School, Chicago
Locations
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The University of Melbourne
Melbourne, Victoria, Australia
Countries
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References
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Lim BW, Hinman RS, Wrigley TV, Sharma L, Bennell KL. Does knee malalignment mediate the effects of quadriceps strengthening on knee adduction moment, pain, and function in medial knee osteoarthritis? A randomized controlled trial. Arthritis Rheum. 2008 Jul 15;59(7):943-51. doi: 10.1002/art.23823.
Other Identifiers
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040850
Identifier Type: -
Identifier Source: org_study_id