Enhanced Community First Responder System Evaluation in Singapore

NCT ID: NCT06530433

Last Updated: 2025-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

165 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-01

Study Completion Date

2028-12-31

Brief Summary

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The rise in out-of-hospital cardiac arrest (OHCA) cases in Singapore highlights the need for effective bystander cardiopulmonary resuscitation (BCPR). Despite many lay responders performing CPR, survival rates with good neurological outcomes have not significantly improved, prompting research into the quality of CPR as a critical factor. The study by Gallagher EJ et al. showed a significant survival improvement with high-quality CPR.

To address this, the Unit of Pre-hospital and Emergency Research (UPEC) trained thousands of community first responders (CFRs) in simplified CPR techniques using hands-only and DA-CPR methods. A significant innovation is the CPRcard®, developed by Laerdal in Norway, which offers real-time feedback on the quality of chest compressions. However, only 36% of CFRs using the CPRcard® achieved the desired compression standards, indicating room for improvement.

The study proposes enhancing CFR support with information communication technology (ICT), enabling two-way audio and one-way video communication between CFRs and dispatchers. This aims to reduce stress among responders, increase their willingness to engage with OHCA alerts, and improve CPR quality.

The clinical trial in Singapore will compare the current system against the enhanced CFR support system (eCSS), focusing on the real-time relay of CPR performance data, communication ease, and implementation factors. The high-quality CFR and OHCA registries in Singapore provide a robust setting for this research, aiming to enhance CPR delivery and improve OHCA outcomes through technology and real-time support.

Detailed Description

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Conditions

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Out-Of-Hospital Cardiac Arrest

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This Health Services research intervention will evaluate effect of live CPR video CPR performance of the volunteer to call-taker in improving CPR Quality and clinical outcomes among the OHCA patients.
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Not possible to mask participants and care provider. Outcome is assessed by a device. Analyst will be masked.

Study Groups

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SoC

Standard of Care

Group Type ACTIVE_COMPARATOR

CPRCard Only

Intervention Type DEVICE

Control arm with standard care of procedure that Bystander using CPRCard only

eCSS

enhanced CFR support system (eCSS)

Group Type EXPERIMENTAL

CPRCard + TCPR Link App and Web

Intervention Type DEVICE

Application that allows responder to perform CPR with two-way audio communication and one-way video streaming to SCDF Dispatcher

Interventions

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CPRCard + TCPR Link App and Web

Application that allows responder to perform CPR with two-way audio communication and one-way video streaming to SCDF Dispatcher

Intervention Type DEVICE

CPRCard Only

Control arm with standard care of procedure that Bystander using CPRCard only

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18 years old and above
* SCDF registered CFRs
* Trial dispatchers with an active account of myResponder® app on their mobile phones

Exclusion Criteria

* The CFRs who are pregnant
* Experiencing any serious physical Conditions
* Mental Health Conditions
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Duke-NUS Graduate Medical School

OTHER

Sponsor Role collaborator

Singapore General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Duke-NUS Medical School

Singapore, Sigapore, Singapore

Site Status

Countries

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Singapore

References

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White AE, Ng HX, Ng WY, Ng EK, Fook-Chong S, Kua PH, Ong ME. Measuring the effectiveness of a novel CPRcard feedback device during simulated chest compressions by non-healthcare workers. Singapore Med J. 2017 Jul;58(7):438-445. doi: 10.11622/smedj.2017072.

Reference Type BACKGROUND
PMID: 28741006 (View on PubMed)

White AE, Ho AF, Shahidah N, Asyikin N, Liew LX, Pek PP, Kua JP, Chia MY, Ng YY, Arulanandam S, Leong SB, Ong ME. An essential review of Singapore's response to out-of-hospital cardiac arrests: improvements over a ten-year period. Singapore Med J. 2021 Aug;62(8):438-443. doi: 10.11622/smedj.2021114.

Reference Type BACKGROUND
PMID: 35001113 (View on PubMed)

Ho AFW, Lim MJR, Earnest A, Blewer A, Graves N, Yeo JW, Pek PP, Tiah L, Ong MEH; Singapore PAROS Investigators. Long term survival and disease burden from out-of-hospital cardiac arrest in Singapore: a population-based cohort study. Lancet Reg Health West Pac. 2022 Dec 28;32:100672. doi: 10.1016/j.lanwpc.2022.100672. eCollection 2023 Mar.

Reference Type BACKGROUND
PMID: 36785853 (View on PubMed)

Chan PS, McNally B, Tang F, Kellermann A; CARES Surveillance Group. Recent trends in survival from out-of-hospital cardiac arrest in the United States. Circulation. 2014 Nov 18;130(21):1876-82. doi: 10.1161/CIRCULATIONAHA.114.009711.

Reference Type BACKGROUND
PMID: 25399396 (View on PubMed)

Gallagher EJ, Lombardi G, Gennis P. Effectiveness of bystander cardiopulmonary resuscitation and survival following out-of-hospital cardiac arrest. JAMA. 1995 Dec 27;274(24):1922-5.

Reference Type BACKGROUND
PMID: 8568985 (View on PubMed)

Bobrow BJ, Vadeboncoeur TF, Stolz U, Silver AE, Tobin JM, Crawford SA, Mason TK, Schirmer J, Smith GA, Spaite DW. The influence of scenario-based training and real-time audiovisual feedback on out-of-hospital cardiopulmonary resuscitation quality and survival from out-of-hospital cardiac arrest. Ann Emerg Med. 2013 Jul;62(1):47-56.e1. doi: 10.1016/j.annemergmed.2012.12.020. Epub 2013 Mar 7.

Reference Type BACKGROUND
PMID: 23465553 (View on PubMed)

Sasson C, Rogers MA, Dahl J, Kellermann AL. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2010 Jan;3(1):63-81. doi: 10.1161/CIRCOUTCOMES.109.889576. Epub 2009 Nov 10.

Reference Type BACKGROUND
PMID: 20123673 (View on PubMed)

Hollenberg J, Herlitz J, Lindqvist J, Riva G, Bohm K, Rosenqvist M, Svensson L. Improved survival after out-of-hospital cardiac arrest is associated with an increase in proportion of emergency crew--witnessed cases and bystander cardiopulmonary resuscitation. Circulation. 2008 Jul 22;118(4):389-96. doi: 10.1161/CIRCULATIONAHA.107.734137. Epub 2008 Jul 7.

Reference Type BACKGROUND
PMID: 18606920 (View on PubMed)

Song J, Guo W, Lu X, Kang X, Song Y, Gong D. The effect of bystander cardiopulmonary resuscitation on the survival of out-of-hospital cardiac arrests: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2018 Oct 11;26(1):86. doi: 10.1186/s13049-018-0552-8.

Reference Type BACKGROUND
PMID: 30309373 (View on PubMed)

Blewer AL, Ho AFW, Shahidah N, White AE, Pek PP, Ng YY, Mao DR, Tiah L, Chia MY, Leong BS, Cheah SO, Tham LP, Kua JPH, Arulanandam S, Ostbye T, Bosworth HB, Ong MEH. Impact of bystander-focused public health interventions on cardiopulmonary resuscitation and survival: a cohort study. Lancet Public Health. 2020 Aug;5(8):e428-e436. doi: 10.1016/S2468-2667(20)30140-7.

Reference Type BACKGROUND
PMID: 32768435 (View on PubMed)

Kim YJ, Ahn S, Sohn CH, Seo DW, Lee YS, Lee JH, Oh BJ, Lim KS, Kim WY. Long-term neurological outcomes in patients after out-of-hospital cardiac arrest. Resuscitation. 2016 Apr;101:1-5. doi: 10.1016/j.resuscitation.2016.01.004. Epub 2016 Jan 28.

Reference Type BACKGROUND
PMID: 26826564 (View on PubMed)

Ong ME, Quah JL, Ho AF, Yap S, Edwin N, Ng YY, Goh ES, Leong BS, Gan HN, Foo DC. National population based survey on the prevalence of first aid, cardiopulmonary resuscitation and automated external defibrillator skills in Singapore. Resuscitation. 2013 Nov;84(11):1633-6. doi: 10.1016/j.resuscitation.2013.05.008. Epub 2013 May 18.

Reference Type BACKGROUND
PMID: 23692983 (View on PubMed)

Related Links

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https://www.myheart.org.sg/wp-content/uploads/2022/10/Singapore-OHCA-Data-Report-2011-2020.pdf

Singapore Heart Foundation. Out-of-Hospital Cardiac Arrest Statistics.

Other Identifiers

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CIRB 2015-2475

Identifier Type: -

Identifier Source: org_study_id

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