Factors Influencing the Mortality of Patients With Subarachnoid Haemorrhage

NCT ID: NCT06490640

Last Updated: 2024-07-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 117 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-03-01
• Study Completion Date: 2024-06-15

Brief Summary

Spontaneous subarachnoid haemorrhage (SAH) is a serious cerebrovascular disease with high morbidity and mortality.Determining the factors associated with mortality in the ICU follow-up and treatment of patients with spontaneous SAH is very important for clarifying these uncertainties and improving ICU outcomes.In the literature, there are very few studies analysing ICU mortality and mortality-related factors in this patient group.The aim of this study was to determine the demographic/clinical characteristics and factors affecting the mortality of spontaneous SAH patients admitted in the ICU.

Detailed Description

Patients aged 18 years and older who were diagnosis of spontaneous SAH and admitted the ICU were included in the study. The diagnosis of spontaneous SAH was based on the brain computed tomography (CT) or lumbar puncture. Patients with a final outcome (survival or mortality) in our centre were included in the analysis were included. Only patients admitted to the ICU for the first time were included. Patients with traumatic SAH, history of significant head trauma in the previous two weeks (any abnormality on brain CT requiring hospitalisation for more than 24 hours), pregnancy and length of ICU stay ≤24 hours were excluded.The clinical and radiological severity of the patients at ICU admission was according to Acute Physiological and Chronic Health Evaluation-II score (APACHE II), Glasgow Coma Scale (GCS), Modified Fisher Scale, World Federation of Neurological Societies (WFNS) and Hunt and Hess (H&H) grading systems.Demographic and clinical data derived and analyzed included age, sex, smoking history, comorbidities. Presenting signs and symptoms, diagnoses responsible for spontaneous SAH (aneurysm, arterial malformation, etc.), site of aneurysm, risk factors, location of the aneurysm, risk factors, blood pressure during ICU admission, and scores from grading systems indicating clinical and radiological severity of the disease were recorded. Procedures for spontaneous SAH, complications during ICU follow-up (vasospasm, meningitis, electrolyte disturbances, rebleeding, DCI, VIP, sepsis/septic shock) and treatments, duration of ICU stay and mechanical ventilation, ICU outcome (survival or mortality), causes of mortality and brain death status were recorded. According to the outcome of the ICU process, the patients were divided into two groups as survival and mortality.

Conditions

Spontaneous Subarachnoid Hemorrhage

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Spontaneous subarachnoid haemorrhage survival cohort

Demographic and clinical data derived and analyzed included age, sex, smoking history, comorbidities. Presenting signs and symptoms, diagnoses responsible for spontaneous SAH (aneurysm, arterial malformation, etc.), site of aneurysm, risk factors, location of the aneurysm, risk factors, blood pressure during ICU admission, and scores from grading systems indicating clinical and radiological severity of the disease were recorded. Procedures for spontaneous SAH, complications during ICU follow-up (vasospasm, meningitis, electrolyte disturbances, rebleeding, DCI, VIP, sepsis/septic shock) and treatments, duration of ICU stay and mechanical ventilation, ICU outcome (survival or mortality), causes of mortality and brain death status were recorded.

Spontaneous subarachnoid haemorrhage survival cohort

Intervention Type: OTHER

consists of surviving patients

Spontaneous subarachnoid haemorrhage mortality cohort

Demographic and clinical data derived and analyzed included age, sex, smoking history, comorbidities. Presenting signs and symptoms, diagnoses responsible for spontaneous SAH (aneurysm, arterial malformation, etc.), site of aneurysm, risk factors, location of the aneurysm, risk factors, blood pressure during ICU admission, and scores from grading systems indicating clinical and radiological severity of the disease were recorded. Procedures for spontaneous SAH, complications during ICU follow-up (vasospasm, meningitis, electrolyte disturbances, rebleeding, DCI, VIP, sepsis/septic shock) and treatments, duration of ICU stay and mechanical ventilation, ICU outcome (survival or mortality), causes of mortality and brain death status were recorded.

Spontaneous subarachnoid haemorrhage mortality cohort

Intervention Type: OTHER

consists of deceased patients

Interventions

Spontaneous subarachnoid haemorrhage survival cohort

consists of surviving patients

Intervention Type: OTHER

Spontaneous subarachnoid haemorrhage mortality cohort

consists of deceased patients

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients aged ≥18 years with a confrmed diagnosis of spontaneous subarachnoid haemorrhage by a brain computed tomography (CT)
• Patients with a final outcome (survival or mortality) in our centre

Exclusion Criteria

• Patients with traumatic SAH
• History of significant head trauma in the previous two weeks (any abnormality on brain CT requiring hospitalisation for more than 24 hours)
• Pregnancy
• Length of intensive care unit stay ≤24 hours

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Melike Cengiz

OTHER

Sponsor Role: lead

Responsible Party

Melike Cengiz

MD,Professor Doctor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ulku Arslan Yildiz, MD

Role: PRINCIPAL_INVESTIGATOR

Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

Murat Yilmaz, Professor

Role: PRINCIPAL_INVESTIGATOR

Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

Onur Cetinkaya, MD

Role: PRINCIPAL_INVESTIGATOR

Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

Locations

Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

Antalya, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

Akdeniz U.

Identifier Type: -

Identifier Source: org_study_id