The Short and Long-term Cardiovascular Consequences of Critical Illness: The C3 Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-08-10

Study Completion Date

2023-12-31

Brief Summary

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The aim this study will be to find out which patients are at risk of heart attacks/strokes up to several years after discharge from an ICU. This study will also investigate whether treatments and events occurring in ICU contribute to this risk.

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Detailed Description

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Undertake a retrospective observational cohort study of patients admitted to intensive care units between 2006 and 2023.

Study Participants: Adult patients admitted to a general adult intensive care unit at one or more of the study sites between 2006 and 1st of August 2023.

Objectives:

To determine the short and long-term cardiovascular consequences of critical illness and identify in-ICU factors that affect them.

To identify the risk factors for new-onset atrial fibrillation/flutter occurring during critical illness.

To study the association between poor cardiovascular function during critical illness and long-term cardiovascular disease.

This study will provide new knowledge about the associations between baseline cardiovascular risk, the disease resulting in ICU admission and therapies / events on ICU with subsequent major adverse cardiac events (MACE), to allow the ongoing risk of these events to be determined. If clinicans can idetnify who is at risk, then risk factors can potentially be modified .

Conditions

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Critical Illness Myocardial Infarction Stroke Atrium; Fibrillation Atrial Flutter

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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ICU

Patients treated on a general adult intensive care unit

Admission to ICU

Intervention Type OTHER

Exposure is admission to an Intensive Care Unit

Interventions

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Admission to ICU

Exposure is admission to an Intensive Care Unit

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 16 years or above.
* Admitted to an intensive care unit at a study site from 2006 onwards

Exclusion Criteria

* Patients that have informed their participating site that they do not wish their electronic records would be used for future research
* Patients who inform us directly that they don't wish their records used in this research study

Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No