Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

83 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-11

Study Completion Date

2019-05-03

Brief Summary

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Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.

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Detailed Description

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Conditions

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Sepsis Diastolic Dysfunction Lung Edema Fluid Overload

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Diastolic Dysfunction

Patients with pre-existing or new diastolic dysfunction.

No interventions assigned to this group

Normal Diastolic Function

Patients with normal diastolic function.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis.

Exclusion Criteria

* Patients with hemodynamically relevant cardiac defects.
* Patients with mitral valve replacement.
* Patients with pericardial effusion.
* Patients with atrial fibrillation.
* Patients with pacemaker therapy.
* Patients with BMI \> 35 kg/m2.
* Patients with poor examination conditions for ultrasound.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No