Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-12-31

Study Completion Date

2026-12-31

Brief Summary

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This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.

The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

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Detailed Description

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The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.

Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Conditions

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Sepsis Severe Sepsis Septic Shock Multi-organ Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Multi-organ failure

Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adults with severe sepsis or septic shock on mechanical ventilation
* Enrolled in the initial six hours of ICU admission

Exclusion Criteria

* Patients with withdrawal or hospice order.
* Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
* Patients with COPD.
* Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No