Platelet Indices in Prediction of Mortality in Critically Ill Septic Patients
NCT ID: NCT04335955
Last Updated: 2023-11-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
54 participants
OBSERVATIONAL
2020-05-01
2020-11-30
Brief Summary
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Platelet indices are a group of parameters that are used to measure the total amount of PLTs, PLTs morphology and proliferation kinetics (2).
The commonly used PLT indices include PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). The MPV refers to the ratio of PCT to PLT count. PDW is numerically equal to the coefficient of PLT volume variation, which is used to describe the dispersion of PLTs volume (3).
It is well known that platelet indices have been applied in the diagnosis of hematological system diseases. In recent years, it has been discovered that these indices are related to the severity of illness and patients' prognosis. Reduction in PLT count is an independent risk factor for critically ill patients in intensive care unit (4).
In addition, Acute Physiology and Chronic Health Evaluation II (APACHE II) System also includes thrombocytopenia as an independent risk factor for mortality (5).
In a recent research, it will be reported that MPV will be rising with interleukin-6 and C-reactive protein in septic premature infants. MPV has been used as predictor of many inflammatory diseases as MPV significantly higher on both day 1 and day 3 in neonatal sepsis (6).
In addition, in patients with cirrhosis and ascites, elevated PDW and MPV will be accurate diagnostic predictors for ascetic fluid infection (7).
MPV and PDW will be used as biomarkers predicting the development of postoperative sepsis in colorectal cancer patient (8).
All these evidences indicated that PLT indices will be considered as indicator in a series of diseases (9).
Advantages of platelet indices are simple, available, cheap tools and routinely done in the hospital laboratory in all critical ill patients and may be a useful, sensitive tool for diagnosis and monitoring these patients especially in limited resource countries as Egypt. However, whether PLT indices are correlated with procalcitonin in assessment the severity of illness is still under research in septic patients
Detailed Description
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The following data will be recorded:
* Demographic data (age, gender and BMI) and cause of sepsis
* Procalcitonin and its correlation with changes in platelet indices
* The odds ratio (OR) for mortality in patients with normal and abnormal platelet indices.
* Sequential organ failure assessment (SOFA) scores.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients with active hemorrhage
* Patients with hematological diseases (including anemia, hypersplenism
* Lymphoma or leukemia
* Rheumatism, and bone marrow diseases)
* Patients who had infused with blood or platelets prior to their admission
* Patients who had used anti-platelet drugs prior to their admission
* Patients who had received radiotherapy or chemotherapy or bone marrow transplantation 1 month prior to admission.
18 Years
65 Years
ALL
No
Sponsors
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Amany Faheem
OTHER
Responsible Party
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Amany Faheem
sponsor investigator
Locations
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Amany Afheem
Tanta, , Egypt
Countries
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Other Identifiers
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Platelet Indices in sepsis
Identifier Type: -
Identifier Source: org_study_id