Association Between Euploid Embryo Grade and Maternal Age

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

502 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-07

Study Completion Date

2025-03-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Background: Advanced maternal age (AMA) is associated with a reduction in live birth rate (LBR) after ART cycles. The main reason for this reduction is the lower number of oocytes aspirated, the number of developing embryos and the low number of euploid embryos available for transfer. The impact of age on success rates after the transfer of an euploid embryo has been a matter of discussion, with a recent meta-analysis showing a reduction in LBR after the transfer of an euploid blastocyst to women of AMA (1). There could be many reasons for this reduced LBR but they can be categorized into two broad categories - the uterus (including the mother's health) and the embryo (including the oocyte and the sperm).

It is possible that factors associated with reduced embryo quality would manifest in a lower embryo grade.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Preimplantation Genetic Diagnosis for the Indication of Advanced Reproductive Age

NCT00646893

Infertility

SUSPENDED PHASE4

Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation

NCT02268123

Male Infertility

COMPLETED

Association Between Embryo Implantation Rate and Maternal Age

NCT05232019

Infertility, Female

COMPLETED

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

NCT07062237

Infertility Male Factor Infertility

RECRUITING NA

Preimplantation Genetic Testing for Aneuploidy of Polar Bodies

NCT04538560

Subfertility

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Objective: To study if there is an association between advanced maternal age and lower embryo grading of euploid embryos.

Hypothesis: Advanced maternal age is associated with a lower embryonic grade in euploid embryos.

Study Design: This is a retrospective cross-sectional study of euploid embryos from patients who have completed IVF with PGT-A testing at a fertility clinic in The Prelude Network (US sites only). A comparison of embryo grade between different age groups (\<35, 40+) will be done after controlling for baseline demographic characteristics.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Fertility

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU)
* PGT biopsy was conducted in 2023,
* PGT biopsy was performed on blastocyst stage embryo,
* PGT-A result is euploid.

Exclusion Criteria

* PGT-A result is mosaic,
* Embryos in which PGT-M was done and were found to be carriers of the mutation,
* Embryos in which PGT-SR was done and were found to be carriers of the structural rearrangement.

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No