Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-21

Study Completion Date

2020-07-03

Brief Summary

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The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.

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Detailed Description

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Effects of ovarian stimulation on human embryo quality is still a subject of study. When natural and stimulated cycles have been compared, no differences have been observed in terms of embryo cleavage capacity, oocyte and embryo aneuploidy rate or incidence of aneuploidy in aborted foetuses. When mild and conventional doses of gonadotropins have been compared, a higher proportion of good morphological quality embryos are observed in the former. On the contrary, we showed that ovarian stimulation does not increase significantly the embryo aneuploidy rate in IVF derived human embryos when unstimulated and stimulated cycles were compared in oocyte donors. In this study, we want to compare the embryo aneuploidy rate between unstimulated and stimulated cycles in infertile patients, subjected to both IVF cycles with blastocyst biopsy and NGS-PGS. A comparison of the morphokinetics will also be performed.

Conditions

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Euploid Embryos

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Natural Cycle

The patient will not undergo hyperstimulation rather a natural cycle

No interventions assigned to this group

Stimulated Cycle

The 80 patients will undergo hyperstimulation cycle as per the clinical practice planned for the patient.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Women
* 30-38 years old (inclusive)
* with regular menstrual cycles (25-35 days)
* AntiMülleriana Hormone \>5 pmol/L.
* Undergoing IVF treatment

Exclusion Criteria

* BMI \>30 kg/m2
* repeated miscarriages
* implantation failure
* uterine or adnexal pathology
* Unable to be treated with gonadotrophins for the ovarian hyperstimulation
* history of low response to ovarian hyperstimulation
* participation in another study with PGS for monogenic pathology
* Cryptozoospermia in male partner

Minimum Eligible Age

30 Years

Maximum Eligible Age

38 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No