Productive Value of Sonographic Measurement of Optic Nerve in Transitional Multiple
NCT ID: NCT06435962
Last Updated: 2024-06-04
Study Results
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Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2024-08-01
2026-03-01
Brief Summary
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Detailed Description
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1 Increasing evidence has demonstrated that neuronal and axonal damage within the central nervous system (CNS) contributes substantially to the development of permanent disability in patients with MS
* 2 Thus, reliable, economic and easily assessable complementary surrogate biomarkers for axonal Degeneration and consequently disability remain to be identified
* 3 The optic nerve can serve as a useful clinical tool for studying these characteristics and can be used to Measure and monitor the pathological process of the disease. The optic nerve is most commonly assessed by ophthalmoscopy and magnetic resonance imaging (MRI), But measurement of the optic nerve diameter (OND) by a simple ultrasound examination and measurement of optic nerve function by visual evoked potential might permit a rough estimation of the extent of brain parenchymal involvement and the consequent global cerebral atrophy and disability In relapsing-remitting MS (RRMS) patients.
The analysis of the diameter of the optic nerve showed that it is possible To detect its atrophy in the affected eyes (with optic neuritis ) and, to a lesser extent, in un affected eye Also the visual evoked potential study has the ability to quantify the unsuspected clinically silent lesions, hence, allows confirming the vague deterioration of visual functions.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Interventions
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sonography
measurement of optic nerve in RRMS by sonography and visual evoked potential( VEP) as correlation of axonal affection in RRMS patient
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Age group from 15 to 50 yrs
3. Patient with RRMS without history of optic neuritis
Exclusion Criteria
2. Medical illness of eye(e.g. diabetes and hypertension)
3. MS patient on fingolimod for 6 months or more
4. Relapsing or use of steroid in the past 3 months
5. Proved alternative diagnosis (neuromyelitis optica )
6. local eye disease or surgery
15 Years
50 Years
ALL
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Randa Alkady
resident doctor
Principal Investigators
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Anwar M Ali, professor
Role: STUDY_DIRECTOR
Assiut University
Central Contacts
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References
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Koraysha NA, Kishk N, Hassan A, Samy El Gendy NM, Shehata HS, Al-Azayem SA, Kamal YS. Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis. Neuropsychiatr Dis Treat. 2019 Sep 6;15:2571-2578. doi: 10.2147/NDT.S216079. eCollection 2019.
De Masi R, Orlando S, Conte A, Pasca S, Scarpello R, Spagnolo P, Muscella A, De Donno A. Transbulbar B-Mode Sonography in Multiple Sclerosis: Clinical and Biological Relevance. Ultrasound Med Biol. 2016 Dec;42(12):3037-3042. doi: 10.1016/j.ultrasmedbio.2016.07.018. Epub 2016 Sep 15.
Other Identifiers
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optic nerve affection in RRMS
Identifier Type: -
Identifier Source: org_study_id
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