VR-Based Optokinetic Stimulation in Multiple Sclerosis

NCT ID: NCT07150520

Last Updated: 2025-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-15

Study Completion Date

2025-10-31

Brief Summary

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The aim of this study is to investigate the acute effects of virtual reality-based optokinetic stimulation on postural sway and motion sickness symptoms in individuals with multiple sclerosis (MS)

Detailed Description

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This study will be conducted at Hacettepe University, Faculty of Physical Therapy and Rehabilitation. It will investigate the acute effects of virtual reality-based optokinetic stimulation (OKS) on postural sway and motion sickness symptoms in individuals with multiple sclerosis (MS). Participants will include MS patients with and without central vestibular dysfunction, as well as age- and sex-matched healthy controls. MS participants will first undergo vestibular function assessment using videonystagmography (VNG). Postural control will then be measured via a force platform under four conditions (bipodal/monopodal, eyes open/closed) before and after a 10-minute OKS session using Oculus Quest 2. Healthy participants will follow the same postural and OKS assessment protocol without VNG.Motion sickness and virtual reality effects will be evaluated using the Simulator Sickness Questionnaire. Data will be analyzed using appropriate parametric or non-parametric tests to compare postural sway and VR-related symptoms across groups, with significance set at p \< 0.05.

Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

All participants will receive the same virtual reality-based optokinetic stimulation protocol. Comparisons will be made between MS patients with and without central vestibular dysfunction and healthy controls
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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MS with Central Vestibular Dysfunction

Participants with multiple sclerosis who have central vestibular dysfunction will receive a 10-minute session of virtual reality-based optokinetic stimulation (OKS) using Oculus Quest 2. Postural sway and motion sickness will be measured before and after the intervention.

Group Type EXPERIMENTAL

Virtual Reality-Based Optokinetic Stimulation (OKS)

Intervention Type DEVICE

A 10-minute session of virtual reality-based optokinetic stimulation (OKS) using the Oculus Quest 2 system. The stimulation speed is set at 40°/s and the direction is determined according to Fukuda test results. Postural sway and motion sickness will be assessed before and after the intervention.

MS without Central Vestibular Dysfunction

Participants with multiple sclerosis without central vestibular dysfunction will receive a 10-minute session of virtual reality-based optokinetic stimulation (OKS) using Oculus Quest 2. Postural sway and motion sickness will be measured before and after the intervention.

Group Type EXPERIMENTAL

Virtual Reality-Based Optokinetic Stimulation (OKS)

Intervention Type DEVICE

A 10-minute session of virtual reality-based optokinetic stimulation (OKS) using the Oculus Quest 2 system. The stimulation speed is set at 40°/s and the direction is determined according to Fukuda test results. Postural sway and motion sickness will be assessed before and after the intervention.

Healthy Controls

Healthy participants will receive a 10-minute session of virtual reality-based optokinetic stimulation (OKS) using Oculus Quest 2. Postural sway and motion sickness will be measured before and after the intervention

Group Type EXPERIMENTAL

Virtual Reality-Based Optokinetic Stimulation (OKS)

Intervention Type DEVICE

A 10-minute session of virtual reality-based optokinetic stimulation (OKS) using the Oculus Quest 2 system. The stimulation speed is set at 40°/s and the direction is determined according to Fukuda test results. Postural sway and motion sickness will be assessed before and after the intervention.

Interventions

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Virtual Reality-Based Optokinetic Stimulation (OKS)

A 10-minute session of virtual reality-based optokinetic stimulation (OKS) using the Oculus Quest 2 system. The stimulation speed is set at 40°/s and the direction is determined according to Fukuda test results. Postural sway and motion sickness will be assessed before and after the intervention.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Be an adult aged 18-55 years
* Have a confirmed diagnosis of MS by a neurologist (for MS groups)
* Not have had a relapse in the last 3 months (for MS patients)
* Have an Expanded Disability Status Scale (EDSS) score of ≤ 4 (for MS patients)
* Be a healthy control with no condition preventing participation

Exclusion Criteria

* Have peripheral vestibular dysfunction (for MS groups)
* Be older than 55 years
* Have any cardiovascular, orthopedic, neurological, or other condition preventing assessments
* Have a history of neurological disorders, head trauma, or chronic psychiatric conditions (for healthy controls)
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hacettepe University

OTHER

Sponsor Role collaborator

Avrasya University

OTHER

Sponsor Role lead

Responsible Party

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Özge Özdemir

M.Sc.

Responsibility Role PRINCIPAL_INVESTIGATOR

Related Links

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Other Identifiers

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2025/102

Identifier Type: -

Identifier Source: org_study_id

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