Cardiac-Control Affecting Learning Through Mindfulness (CALM)
NCT ID: NCT06410157
Last Updated: 2025-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
240 participants
INTERVENTIONAL
2025-01-14
2027-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Increase Oscillation
Participants will breath at a slow "resonance" frequency during a breath-focused mindfulness practice and receive biofeedback to increase heart rate oscillation.
Daily practice
Participants will be asked to undergo daily mindfulness practice while regulating (either increase or decrease) heart rate oscillation.
Decrease Oscillation
Participants' breathing will not be fixed to particular frequency during a breath-focused mindfulness practice and they will receive biofeedback to decrease heart rate oscillation.
Daily practice
Participants will be asked to undergo daily mindfulness practice while regulating (either increase or decrease) heart rate oscillation.
Interventions
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Daily practice
Participants will be asked to undergo daily mindfulness practice while regulating (either increase or decrease) heart rate oscillation.
Eligibility Criteria
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Inclusion Criteria
* Black/African-American or White/European-American
* Aged between 50-70 years old
* Non-pregnant and non-menstruating (for at least the past year)
* Have normal or corrected-to-normal vision and hearing
* Have reliable access to wifi
* Have an email account that you check regularly
* Have a phone that receives text messages
* Agree to provide blood and urine samples at two campus visits
* Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits
Exclusion Criteria
* Have cognitive impairment
* Have regularly played Lumosity games in the past 6 months
* Have any conditions listed below that are not safe for MRI
* \*Metal in any parts of your body
* Claustrophobia
* Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
* Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
* Cardiac pacemaker
* Implanted cardiac defibrillator
* Aneurysm clip or brain clip
* Carotid artery vascular clamp
* Neurostimulator
* Insulin or infusion pump
* Spinal fusion stimulator
* Cochlear, otologic, ear tubes or ear implant
* Prosthesis (eye/orbital, penile, etc.)
* Implant held in place by a magnet
* Heart valve prosthesis
* Artificial limb or joint
* Other implants in body or head
* Electrodes (on body, head or brain)
* Intravascular stents, filters
* Shunt (spinal or intraventricular)
* Vascular access port or catheters
* IUD
* Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI
* Shrapnel, buckshot, or bullets
* Tattooed eyeliner or eyebrows
* Body piercing(s) that cannot be removed for MRI
* Metal fragments (eye, head, ear, skin)
* Internal pacing wires
* Aortic clips
* Metal or wire mesh implants
* Wire sutures or surgical staples
* Harrington rods (spine)
* Bone/joint pin, screw, nail, wire, plate
* Wig or toupee that cannot be removed for MRI
* Hair implants that involve staples or metal
* Hearing aid(s) that cannot be removed for MRI
* Dentures or retainers that cannot be removed for MRI
50 Years
70 Years
ALL
Yes
Sponsors
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University of California, Irvine
OTHER
National Institute on Aging (NIA)
NIH
University of Southern California
OTHER
Responsible Party
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Mara Mather
Professor
Locations
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University of Southern California
Los Angeles, California, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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UP-21-00357-main
Identifier Type: -
Identifier Source: org_study_id
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