Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio

NCT ID: NCT06403722

Last Updated: 2024-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

190 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-15

Study Completion Date

2024-01-30

Brief Summary

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Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110. Data were collected on their clinical course prior to termination of pregnancy, using the last reported sFlt-1/PlGF ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.

Detailed Description

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Conditions

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Hypertension in Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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sFlt-1/PlGF: 110-205

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 110-205.

Standard of care

Intervention Type DIAGNOSTIC_TEST

No intervention. Clinical evolution was recorded, looking for perinatal complications.

sFlt-1/PlGF: 206-654

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 206-654.

Standard of care

Intervention Type DIAGNOSTIC_TEST

No intervention. Clinical evolution was recorded, looking for perinatal complications.

sFlt-1/PlGF: 655-999

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 655-999.

Standard of care

Intervention Type DIAGNOSTIC_TEST

No intervention. Clinical evolution was recorded, looking for perinatal complications.

sFlt-1/PlGF > 1000

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF above 1000.

Standard of care

Intervention Type DIAGNOSTIC_TEST

No intervention. Clinical evolution was recorded, looking for perinatal complications.

Interventions

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Standard of care

No intervention. Clinical evolution was recorded, looking for perinatal complications.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of hypertensive disorder of pregnancy
* Gestational age between 24 - 36 6/7
* sFlt-1/PlGF \> 110

Exclusion Criteria

* Gestational age below 23 6/7 weeks and above 37 weeks at the moment of admission.
* Absence of sFLt-1/PlGF ratio result.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Saint Thomas Hospital, Panama

OTHER

Sponsor Role lead

Responsible Party

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Osvaldo A. Reyes T.

Head of the research deparment

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Saint Thomas H

Panama City, , Panama

Site Status

Countries

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Panama

Other Identifiers

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2023-631

Identifier Type: -

Identifier Source: org_study_id

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