Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

262 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-08-31

Study Completion Date

2011-12-31

Brief Summary

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For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.

Detailed Description

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A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).

Conditions

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Preeclampsia

Keywords

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preeclampsia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Women considered as a potential participant in this research were patients regularly visited at the prenatal care of Cha hospital in Seoul, Korea

Exclusion Criteria

* early onset and cases not to measure the sFlt/PlGF ratio and other markers
* twin pregnancy
* Chronic hypertension
* prior history of preeclampsia
* pregestational diabetes mellitus
* gestational diabetes mellitus
* patients delivered before 35 weeks of gestation
* preeclamptic patients with onset before 35 weeks of gestation
* patients with body mass index 25kg/m2 or greater
* maternal age 40 years older

Minimum Eligible Age

20 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Responsible Party

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Dong Hyun Cha

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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PrePark

Identifier Type: -

Identifier Source: org_study_id