Liver Transplantation for Hepatocellular Carcinoma Arising in Non-cirrhotic Liver: a Propensity Score-matched Retrospective Cohort Study of Two National Databases

NCT ID: NCT06364839

Last Updated: 2024-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-20

Study Completion Date

2024-03-25

Brief Summary

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Background: Majority of liver transplantation (LT) recipients for hepatocellular carcinoma (HCC) were concomitant with liver cirrhosis, while few researches focusing on recipients without cirrhosis. Here we aim to investigate the prognosis of non-cirrhosis HCC recipients, expecting to provide theoretical basis for further improvement of these patients.

Methods: This retrospective study analyze outcomes between adult HCC recipients arising in non-cirrhotic and cirrhotic liver from two national databases (CLTR and UNOS, January 2015 to December 2020). Based on important variables, 1:2 and 1:1 propensity score matching (PSM) were performed respectively.

Detailed Description

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Conditions

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Hepatocellular Carcinoma, Non-cirrhotic Liver

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* liver transplants, performed from January 2015 to December 2020

Exclusion Criteria

* pediatric LT; LT for non-tumor lesions; LT for other malignant tumors (cholangiocarcinoma, carcinoma of gallbladder, mixed carcinoma, and secondary tumors); re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 1 week due to post-operative hemorrhage after LT.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xiao Xu

OTHER

Sponsor Role lead

Responsible Party

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Xiao Xu

Principal Investigator, Clinical Professor,PHD,MD

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Xiao Xu

Hangzhou, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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CT2024-ZJU-OBS7

Identifier Type: -

Identifier Source: org_study_id

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