Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

NCT ID: NCT05355662

Last Updated: 2022-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

11569 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-01

Study Completion Date

2018-12-31

Brief Summary

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Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Detailed Description

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Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Conditions

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Liver Transplantation Hepatocellular Carcinoma Survival

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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OLDs

Older liver donors (OLDs) and recipients were defined as individuals whose donor age was equal to or greater than 60 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Age

Intervention Type OTHER

The study was retrospective and did not involve the application of interventions.

ILDs

Ideal or young liver donors (ILDs) and recipients were defined as donors aged 18-40 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Age

Intervention Type OTHER

The study was retrospective and did not involve the application of interventions.

ALDs

Average liver donors (ALDs) and recipients were defined as donor age 40-59 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Age

Intervention Type OTHER

The study was retrospective and did not involve the application of interventions.

Interventions

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Age

The study was retrospective and did not involve the application of interventions.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Recipient age ≥ 18 years and \< 65 years.
2. Donor age ≥ 18 years.

Exclusion Criteria

1. Recipient age \<18 years or ≥65 years.
2. Donor age \<18 years.
3. Patients who died within 30 days after transplantation.
4. Secondary liver transplantation.
5. Multiple organ transplantation.
6. Patients with incomplete data or failed follow-up.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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First Affiliated Hospital Xi'an Jiaotong University

OTHER

Sponsor Role lead

Responsible Party

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Hu Liangshuo

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bo Wang, MD PhD

Role: STUDY_CHAIR

First Affiliated Hospital Xi'an Jiaotong University

Other Identifiers

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No. XJTU1AF-CRF-2019-029

Identifier Type: -

Identifier Source: org_study_id

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